Recombinant Human MMP-1 Protein, CF | R&D Systems 901-MP-010 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human MMP-1 Protein, CF

catalog :

901-MP-010

quantity :

10 ug

price :

410 USD

more info or order :

R&D Systems product webpage

citations: 16

Reference
Wu Y, Tang Y, Zhang X, Chu Z, Liu Y, Tang C. MMP-1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via the JNK and ERK pathway. Int J Biochem Cell Biol. 2020;129:105880 pubmed publisher
Kumar L, Colomb W, Czerski J, Cox C, Sarkar S. Efficient protease based purification of recombinant matrix metalloprotease-1 in E. coli. Protein Expr Purif. 2018;148:59-67 pubmed publisher
Willumsen N, Bager C, Leeming D, Bay Jensen A, Karsdal M. Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non-Small Cell Lung Cancer. Neoplasia. 2017;19:271-278 pubmed publisher
Naveed S, Clements D, Jackson D, Philp C, Billington C, Soomro I, et al. Matrix Metalloproteinase-1 Activation Contributes to Airway Smooth Muscle Growth and Asthma Severity. Am J Respir Crit Care Med. 2017;195:1000-1009 pubmed publisher
Gopal S, Greening D, Zhu H, Simpson R, Mathias R. Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis. Sci Rep. 2016;6:28321 pubmed publisher
Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, et al. TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts. J Immunol. 2014;192:4977-88 pubmed publisher
Djokic J, Fagotto Kaufmann C, Bartels R, Nelea V, Reinhardt D. Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimers. J Biol Chem. 2013;288:22821-35 pubmed publisher
Zhang Y, Mao X, Schwend T, Littlechild S, Conrad G. Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases. Invest Ophthalmol Vis Sci. 2013;54:1014-25 pubmed publisher
Devel L, Beau F, Amoura M, Vera L, Cassar Lajeunesse E, Garcia S, et al. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J Biol Chem. 2012;287:26647-56 pubmed publisher
Zhao X, Qureshi F, Eastman P, Manning W, Alexander C, Robinson W, et al. Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis. J Immunol Methods. 2012;378:72-80 pubmed publisher
Gonzalez R, Seurynck Servoss S, Crowley S, Brown M, Omenn G, Hayes D, et al. Development and validation of sandwich ELISA microarrays with minimal assay interference. J Proteome Res. 2008;7:2406-14 pubmed publisher
Milward E, Kim K, Szklarczyk A, Nguyen T, Melli G, Nayak M, et al. Cleavage of myelin associated glycoprotein by matrix metalloproteinases. J Neuroimmunol. 2008;193:140-8 pubmed
Lauder S, Carty S, Carpenter C, Hill R, Talamas F, Bondeson J, et al. Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis. Rheumatology (Oxford). 2007;46:752-8 pubmed
Masckauchan T, Agalliu D, Vorontchikhina M, Ahn A, Parmalee N, Li C, et al. Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2. Mol Biol Cell. 2006;17:5163-72 pubmed
Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed
Haug C, Lenz C, Diaz F, Bachem M. Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells. Arterioscler Thromb Vasc Biol. 2004;24:1823-9 pubmed

product information

brand :

R&D Systems

master code :

901-MP

SKU :

901-MP-010

product name :

Recombinant Human MMP-1 Protein, CF

description :

The Recombinant Human MMP-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human MMP-1 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

MMP-1

category :

Proteins and Enzymes

sizes available :

10 ug

buffer :

Supplied as a 0.2 µm filtered solution in MES, NaCl, CaCl2 and Brij-35.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

52-55 kDa, reducing conditions

theoretical molecular weight :

52 kDa

gene symbol :

MMP1

details of functionality :

Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 (Catalog # ES010 ). The specific activity is 400 pmol/min/µg, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P03956

applications :

Enzyme Activity

source :

NS0-derived Recombinant Human MMP-1 Protein, CF

USD :

410

USD 2023 :

410 USD

alt names :

CLGmatrix metalloprotease 1, CLGN, EC 3.4.24, EC 3.4.24.7, Fibroblast collagenase, interstitial collagenase, matrix metallopeptidase 1 (interstitial collagenase), matrix metalloproteinase 1 (interstitial collagenase), Matrix metalloproteinase-1, MMP1, MMP-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage