Recombinant Human PD-1 His Tagged Protein, CF | R&D Systems 8986-PD-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human PD-1 His Tagged Protein, CF

catalog :

8986-PD-100

quantity :

100 ug

price :

425 USD

citations: 8

Reference
Carter R, Alanazi F, Sharp A, Roman J, Luchini A, Liotta L, et al. Identification of the functional PD-L1 interface region responsible for PD-1 binding and initiation of PD-1 signaling. J Biol Chem. 2023;299:105353 pubmed publisher
Kang C, Lee S, Ahn T, Seo D, Ko B, Jung M, et al. Antibody-dependent cellular cytotoxicity-null effector developed using mammalian and plant GlycoDelete platform. Sci Rep. 2022;12:19030 pubmed publisher
Phakham T, Boonkrai C, Wongtangprasert T, Audomsun T, Attakitbancha C, Saelao P, et al. Highly efficient hybridoma generation and screening strategy for anti-PD-1 monoclonal antibody development. Sci Rep. 2022;12:17792 pubmed publisher
Issafras H, Fan S, Tseng C, Cheng Y, Lin P, Xiao L, et al. Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy. PLoS ONE. 2021;16:e0257972 pubmed publisher
Edwards C, Sette A, Cox C, Di Fiore B, Wyre C, Sydoruk D, et al. The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity. Br J Cancer. 2021;: pubmed publisher
Metz M, Sussman G, Gagnon R, Staubach P, Tanus T, Yang W, et al. Fenebrutinib in H1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial. Nat Med. 2021;27:1961-1969 pubmed publisher
Brown M, Bedinger D, Lilov A, Rathanaswami P, V squez M, Durand S, et al. Assessing the binding properties of the anti-PD-1 antibody landscape using label-free biosensors. PLoS ONE. 2020;15:e0229206 pubmed publisher
Crauwels M, Van Vaerenbergh N, Kulaya N, Vincke C, D Huyvetter M, Devoogdt N, et al. Reshaping nanobodies for affinity purification on protein a. N Biotechnol. 2020;57:20-28 pubmed publisher

product information

master code :

8986-PD

SKU :

8986-PD-100

product name :

Recombinant Human PD-1 His Tagged Protein, CF

unit size :

100 ug

description :

The Recombinant Human PD-1 His Tagged Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human PD-1 His Tagged Protein, CF has been validated for the following applications: Bioactivity.

target :

PD-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

32 - 44 kDa, under reducing conditions.

theoretical molecular weight :

17 kDa

gene symbol :

PDCD1

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human PD-1 is immobilized at 1 ╡g/mL (100 ╡L/well), the concentration of Recombinant Human B7-H1/PD-L1 Fc Chimera (Catalog # 156-B7 ) that produces 50% of the optimal binding response is approximately 0.3-1.8 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q15116.3

applications :

Bioactivity

source long :

Human embryonic kidney cell, HEK293-derived human PD-1 protein Leu25-Thr168, with a C-terminal 6-His tag

source short :

HEK293

extended description :

Analyzed by SEC-MALS

USD :

425 USD

product details :

Analyzed by SEC-MALS

alt names :

CD279, CD279 antigen, hPD-1, PD1, PD1hPD-l, PDCD1, programmed cell death 1, programmed cell death protein 1, Protein PD-1, SLEB2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.