Recombinant Human Active p70 S6 Kinase Protein, CF | R&D Systems 896-KS product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Active p70 S6 Kinase Protein, CF

catalog :

896-KS

quantity :

10 ug

price :

369 USD

citations: 5

Reference
Nam K, Yi S, Nam G, Noh J, Park J, Lee M, et al. Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer. BMC Cancer. 2019;19:773 pubmed publisher
Chen M, Wan L, Zhang J, Zhang J, Méndez L, Clohessy J, et al. Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nat Commun. 2018;9:159 pubmed publisher
Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017;543:728-732 pubmed publisher
Lee H, Mustafa A, Hudes G, Kruger W. Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. PLoS ONE. 2015;10:e0131464 pubmed publisher
Ip C, Cheung A, Ngan H, Wong A. p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene. 2011;30:2420-32 pubmed publisher

product information

brand :

R&D Systems

master code :

896-KS

SKU :

896-KS-010

product name :

Recombinant Human Active p70 S6 Kinase Protein, CF

description :

The Recombinant Human Active p70 S6 Kinase Protein, CF from R&D Systems is derived from Sf 9 (baculovirus). The Recombinant Human Active p70 S6 Kinase Protein, CF has been validated for the following applications: Bioactivity.

target :

p70 S6 Kinase/S6K

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Supplied in 50 mM sodium phosphate (pH 7.0), 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, and 25% glycerol.

conjugate :

Unconjugated

purity :

>70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane.

species :

Human

observed molecular weight :

76 kDa

gene symbol :

RPS6KB1

details of functionality :

The activity of p70S6K is 65-89 nmol/min/mg using a synthetic peptide substrate (CKRRRLASLR) (see Activity Assay Protocol).

catalog number base :

896-KS

accessionNumbers :

NM_003161

applications :

Bioactivity

source :

Spodoptera frugiperda , Sf 9 (baculovirus)-derived human p70 S6 Kinase protein

2020 USD :

369

2021 USD :

369 USD

alt names :

EC 2.7.11, EC 2.7.11.1, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6 kinase, alpha 1,70 kDa ribosomal protein S6 kinase 1, p70 S6 kinase, alpha 2, p70 S6KA, p70 S6K-alpha, p70(S6K)-alpha, p70-alpha, p70-S6K, P70S6K1, PS6K, ribosomal protein S6 kinase beta-1, Ribosomal protein S6 kinase I, ribosomal protein S6 kinase, 70kD, polypeptide 1, ribosomal protein S6 kinase, 70kDa, polypeptide 1, RPS6KB1, S6K, S6K1, S6K1p70-S6K 1, S6K-beta-1, serine/threonine kinase 14 alpha, Serine/threonine-protein kinase 14A, STK14A

storage :

This product is stable at Avoid repeated freeze-thaw cycles.