Recombinant Human IL-6/IL-6R alpha Protein Chimera | R&D Systems 8954-SR-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-6/IL-6R alpha Protein Chimera

catalog :

8954-SR-025

quantity :

25 ug

price :

413 USD

citations: 13

Reference
Vazquez E, Richter F, Natura G, K xf6 nig C, Eitner A, Schaible H. Direct Effects of the Janus Kinase Inhibitor Baricitinib on Sensory Neurons. Int J Mol Sci. 2024;25: pubmed publisher
Jeong Y, Park S, Park Y, Kim L, Lee H, Kim H, et al. Anti-inflammatory effect of the combined treatment of LMT-28 and kaempferol in a collagen-induced arthritis mouse model. PLoS ONE. 2024;19:e0302119 pubmed publisher
Martin E, Winter S, Garcin C, Tanita K, Hoshino A, Lenoir C, et al. Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency. Nature. 2024;628:620-629 pubmed publisher
Sarieva K, Hildebrand F, Kagermeier T, Yent xfc r Z, Becker K, Mayer S. Pluripotent stem cell-derived neural progenitor cells can be used to model effects of IL-6 on human neurodevelopment. Dis Model Mech. 2023;16: pubmed publisher
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles Smith N, et al. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proc Natl Acad Sci U S A. 2023;120:e2306965120 pubmed publisher
Leng K, Rose I, Kim H, Xia W, Romero Fernandez W, Rooney B, et al. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022;25:1528-1542 pubmed publisher
Cai Z, Tian S, Klein T, Tu L, Geenen L, Koudstaal T, et al. Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα. Sci Rep. 2022;12:12326 pubmed publisher
Chou C, Hua K, Chen M, Wu C, Hsu C, Wang J, et al. Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation. MAbs. 2022;14:2029675 pubmed publisher
Carbotti G, Dozin B, Martini S, Giordano C, Scordamaglia F, Croce M, et al. IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells. Cancers (Basel). 2021;13: pubmed publisher
Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed publisher
Dong J, Viswanathan S, Adami E, Singh B, Chothani S, Ng B, et al. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nat Commun. 2021;12:66 pubmed publisher
Kretschmer T, Schulze Edinghausen M, Turnwald E, Janoschek R, Bae Gartz I, Zentis P, et al. Effect of Maternal Obesity in Mice on IL-6 Levels and Placental Endothelial Cell Homeostasis. Nutrients. 2020;12: pubmed publisher
Ohta R, Sugimura R, Niwa A, Saito M. Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp. 2019;: pubmed publisher

product information

master code :

8954-SR

SKU :

8954-SR-025

product name :

Recombinant Human IL-6/IL-6R alpha Protein Chimera

unit size :

25 ug

description :

The Recombinant Human IL-6/IL-6R alpha Protein Chimera from R&D Systems is derived from HEK293. The Recombinant Human IL-6/IL-6R alpha Protein Chimera has been validated for the following applications: Bioactivity.

target :

IL-6/IL-6R alpha Complex

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

78-93 kDa, reducing conditions

theoretical molecular weight :

59 kDa

gene symbol :

IL6

details of functionality :

Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2.5-12.5 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P08887 (IL-6 R alpha) P05231 (IL-6)

applications :

Bioactivity

source long :

Human embryonic kidney cell, HEK293-derived human IL-6/IL-6R alpha Complex protein Human IL-6R alpha (Leu20-Asp358) Accession # P08887 GGGSGGGSGGGS Human IL-6 Val30-Met212 Accession # P05231 N-terminus C-terminus

source short :

HEK293

USD :

413 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.