Recombinant Human IL-6/IL-6R alpha Protein Chimera | R&D Systems 8954-SR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-6/IL-6R alpha Protein Chimera

catalog :

8954-SR-025

quantity :

25 ug

price :

388 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Carbotti G, Dozin B, Martini S, Giordano C, Scordamaglia F, Croce M, et al. IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells. Cancers (Basel). 2021;13: pubmed publisher
Dong J, Viswanathan S, Adami E, Singh B, Chothani S, Ng B, et al. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nat Commun. 2021;12:66 pubmed publisher
Kretschmer T, Schulze Edinghausen M, Turnwald E, Janoschek R, Bae Gartz I, Zentis P, et al. Effect of Maternal Obesity in Mice on IL-6 Levels and Placental Endothelial Cell Homeostasis. Nutrients. 2020;12: pubmed publisher

product information

brand :

R&D Systems

master code :

8954-SR

SKU :

8954-SR-025

product name :

Recombinant Human IL-6/IL-6R alpha Protein Chimera

description :

The Recombinant Human IL-6/IL-6R alpha Protein Chimera from R&D Systems is derived from HEK293. The Recombinant Human IL-6/IL-6R alpha Protein Chimera has been validated for the following applications: Bioactivity.

target :

IL-6/IL-6R alpha Complex

category :

Proteins and Enzymes

sizes available :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

78-93 kDa, reducing conditions

theoretical molecular weight :

59 kDa

gene symbol :

IL6

details of functionality :

Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2.5-12.5 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P08887 (IL-6 R alpha) P05231 (IL-6)

applications :

Bioactivity

source :

HEK293-derived Recombinant Human IL-6/IL-6R alpha Protein Chimera

USD :

388

USD 2023 :

388 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage