Recombinant Human IL-6/IL-6R alpha Protein Chimera, CF | R&D Systems 8954-SR-025/CF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-6/IL-6R alpha Protein Chimera, CF

catalog :

8954-SR-025/CF

quantity :

25 ug

price :

413 USD

citations: 6

Reference
Leng K, Rose I, Kim H, Xia W, Romero Fernandez W, Rooney B, et al. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022;25:1528-1542 pubmed publisher
Cai Z, Tian S, Klein T, Tu L, Geenen L, Koudstaal T, et al. Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα. Sci Rep. 2022;12:12326 pubmed publisher
Carbotti G, Dozin B, Martini S, Giordano C, Scordamaglia F, Croce M, et al. IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells. Cancers (Basel). 2021;13: pubmed publisher
Dong J, Viswanathan S, Adami E, Singh B, Chothani S, Ng B, et al. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nat Commun. 2021;12:66 pubmed publisher
Kretschmer T, Schulze Edinghausen M, Turnwald E, Janoschek R, Bae Gartz I, Zentis P, et al. Effect of Maternal Obesity in Mice on IL-6 Levels and Placental Endothelial Cell Homeostasis. Nutrients. 2020;12: pubmed publisher
Ohta R, Sugimura R, Niwa A, Saito M. Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition. J Vis Exp. 2019;: pubmed publisher

product information

master code :

8954-SR/CF

SKU :

8954-SR-025/CF

product name :

Recombinant Human IL-6/IL-6R alpha Protein Chimera, CF

unit size :

25 ug

description :

The Recombinant Human IL-6/IL-6R alpha Protein Chimera, CF from R&D Systems is derived from HEK293. The Recombinant Human IL-6/IL-6R alpha Protein Chimera, CF has been validated for the following applications: Bioactivity.

target :

IL-6/IL-6R alpha Complex

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

78-93 kDa, reducing conditions

theoretical molecular weight :

59 kDa

gene symbol :

IL6

details of functionality :

Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2.5-12.5 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P08887 (IL-6 R alpha) P05231 (IL-6)

applications :

Bioactivity

source long :

Human embryonic kidney cell, HEK293-derived human IL-6/IL-6R alpha Complex protein Human IL-6R alpha (Leu20-Asp358) Accession # P08887 GGGSGGGSGGGS Human IL-6 Val30-Met212 Accession # P05231 N-terminus C-terminus

source short :

HEK293

USD :

413 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.