Recombinant Human XIAP (BIR3) Protein, CF | R&D Systems 895-XB-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human XIAP (BIR3) Protein, CF

catalog :

895-XB-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 2

Reference
Shibata N, Shimokawa K, Nagai K, Ohoka N, Hattori T, Miyamoto N, et al. Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase. Sci Rep. 2018;8:13549 pubmed publisher
Shibata N, Miyamoto N, Nagai K, Shimokawa K, Sameshima T, Ohoka N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017;108:1657-1666 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

895-XB

SKU :

895-XB-050

product name :

Recombinant Human XIAP (BIR3) Protein, CF

Description :

The Recombinant Human XIAP (BIR3) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human XIAP (BIR3) Protein, CF has been validated for the following applications: Inhibition Activity.

target :

XIAP

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Supplied as a 0.2 µm filtered solution in HEPES, NaCl and DTT.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

11 kDa, reducing conditions

theoretical molecular weight :

13 kDa

gene symbol :

XIAP

details of functionality :

Measured by its ability to inhibit DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP. The IC50 for this effect is 300 nM. Optimal dilutions should be determined by each laboratory for each application.

accessionNumbers :

P98170

applications :

Inhibition Activity

source :

E. coli-derived Recombinant Human XIAP (BIR3) Protein

USD :

423 USD

alt names :

API3X-linked inhibitor of apoptosis protein, apoptosis inhibitor 3, baculoviral IAP repeat-containing 4, baculoviral IAP repeat-containing protein 4, BIRC4, BIRC4XLP2, E3 ubiquitin-protein ligase XIAP, EC 6.3.2.-, hIAP3, hIAP-3, hILP, IAP3, IAP-3, IAP-like protein, ILP, ILP1, Inhibitor of apoptosis protein 3, MIHA, X-linked IAP, X-linked inhibitor of apoptosis

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage