Recombinant Mouse GDF-15 Protein, CF | R&D Systems 8944-GD-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse GDF-15 Protein, CF

catalog :

8944-GD-025

quantity :

25 ug

price :

551 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Li W, He S, Tan J, Li N, Zhao C, Wang X, et al. Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype. Proc Natl Acad Sci U S A. 2024;121:e2316161121 pubmed publisher
Haensel D, Dániel B, Gaddam S, Pan C, Fabo T, Bjelajac J, et al. Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche. Nat Commun. 2023;14:2685 pubmed publisher
Wang W, Yang X, Dai J, Lu Y, Zhang J, Keller E. Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion. Oncogene. 2019;38:4540-4559 pubmed publisher

product information

master code :

8944-GD

SKU :

8944-GD-025

product name :

Recombinant Mouse GDF-15 Protein, CF

unit size :

25 ug

description :

The Recombinant Mouse GDF-15 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse GDF-15 Protein, CF has been validated for the following applications: Bioactivity.

target :

GDF-15

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in HCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

9-13 kDa, reducing conditions

theoretical molecular weight :

13 kDa

gene symbol :

Gdf15

details of functionality :

Measured by its binding ability in a functional ELISA. Recombinant Mouse GDF-15 (Catalog # 8944-GD) binds to Recombinant Mouse GFR alpha -like Fc Chimera (Catalog # 9844-GR ) with an ED50 of 0.500-5.00 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q9Z0J7

applications :

Bioactivity

source long :

E. coli -derived mouse GDF-15 protein Ser189-Ala303

source short :

E. coli

USD :

551 USD

alt names :

GDF15, growth differentiation factor 15, growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC-1, MIC-1NSAID-activated gene 1 protein, MIC1Prostate differentiation factor, NAG-1, NAG-1NSAID-regulated gene 1 protein, NSAID (nonsteroidal inflammatory drug)-activated protein 1, PDF, PDFGDF-15, PLAB, PLABNRG-1, Placental bone morphogenetic protein, Placental TGF-beta, PTGF-beta, PTGFBPTGF-beta

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage