Recombinant Human Bcl-xL (minus C-Terminus) Protein, CF | R&D Systems 894-BX product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Bcl-xL (minus C-Terminus) Protein, CF

catalog :

894-BX

quantity :

50 ug

price :

369 USD

citations: 3

Reference
Ramsey H, Fischer M, Lee T, Gorska A, Arrate M, Fuller L, et al. A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia. Cancer Discov. 2018;8:1566-1581 pubmed publisher
Wang Y, Liang B, Lau W, Du Y, Guo R, Yan Z, et al. Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling. Autophagy. 2017;13:1855-1869 pubmed publisher
Ghosh J, Shenoy A, Clark J. Interactions between important regulatory proteins and human alphaB crystallin. Biochemistry. 2007;46:6308-17 pubmed

product information

brand :

R&D Systems

master code :

894-BX

SKU :

894-BX-050

product name :

Recombinant Human Bcl-xL (minus C-Terminus) Protein, CF

description :

The Recombinant Human Bcl-xL (minus C-Terminus) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Bcl-xL (minus C-Terminus) Protein, CF has been validated for the following applications: Inhibition Activity.

target :

Bcl-xL

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Supplied as a 0.2 µm filtered solution in HEPES and KCl.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

30 kDa, under reducing conditions

theoretical molecular weight :

24 kDa

gene symbol :

BCL2L1

details of functionality :

Measured by its ability to inhibit Caspase-8-cleaved BID-mediated release of cytochrome c from isolated mouse liver mitochondria using the Rat/Mouse Cytochrome c Quantikine ELISA (Catalog # MCTC0 ) to quantify cytochrome c. The typical EC50 is 250 nM in the presence of 54 nM Recombinant Human BID Caspase-8-cleaved (Catalog # 882-B8 ). Optimal dilutions should be determined by each laboratory for each application.

catalog number base :

894-BX

accessionNumbers :

CAA80661

applications :

Inhibition Activity

source :

E. coli -derived human Bcl-xL protein Ser2-Arg212, with a C-terminal 6-His tag

2020 USD :

369

2021 USD :

369 USD

alt names :

Apoptosis regulator Bcl-X, bcl2-L-1, BCL2-like 1, bcl-2-like protein 1, BCLXBCL2LBcl-X, bcl-xL, BclxL, BCL-XL/S, bcl-xS, BCLXS, DKFZp781P2092

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.