Recombinant Mouse S100A8/S100A9 Heterodimer Protein, CF | R&D Systems 8916-S8-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse S100A8/S100A9 Heterodimer Protein, CF

catalog :

8916-S8-050

quantity :

50 ug

price :

432 USD

citations: 8

Reference
Franz S, Torregrossa M, Anderegg U, Ertel A, Saalbach A. Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic Wounds. Int J Mol Sci. 2024;25: pubmed publisher
Chen J, Chen C, Wang L, Feng X, Chen Y, Zhang R, et al. Identification of S100A8/A9 involved in thromboangiitis obliterans development using tandem mass tags-labeled quantitative proteomics analysis. Cell Signal. 2024;120:111199 pubmed publisher
Maehara N, Taniguchi K, Okuno A, Ando H, Hirota A, Li Z, et al. AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke. Cell Rep. 2021;36:109693 pubmed publisher
Bisson D, Sheng K, Kocabas S, Krock E, Teles A, Saran N, et al. Toll-like receptor involvement in adolescent scoliotic facet joint degeneration. J Cell Mol Med. 2020;24:11355-11365 pubmed publisher
Wu M, Xu L, Wang Y, Zhou N, Zhen F, Zhang Y, et al. S100A8/A9 induces microglia activation and promotes the apoptosis of oligodendrocyte precursor cells by activating the NF-κB signaling pathway. Brain Res Bull. 2018;143:234-245 pubmed publisher
Gong H, Su W, Cao Z, Lian Y, Peng W, Liu Y, et al. Hippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice. J Neuroinflammation. 2018;15:252 pubmed publisher
Basu A, Munir S, Mulaw M, Singh K, Crisan D, Sindrilaru A, et al. A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells associated with Enhanced Wound Healing. Sci Rep. 2018;8:6205 pubmed publisher
Son S, Hwang I, Han S, Shin J, Shin O, Yu J. Advanced glycation end products impair NLRP3 inflammasome-mediated innate immune responses in macrophages. J Biol Chem. 2017;292:20437-20448 pubmed publisher

product information

master code :

8916-S8

SKU :

8916-S8-050

product name :

Recombinant Mouse S100A8/S100A9 Heterodimer Protein, CF

unit size :

50 ug

description :

The Recombinant Mouse S100A8/S100A9 Heterodimer Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse S100A8/S100A9 Heterodimer Protein, CF has been validated for the following applications: Bioactivity.

target :

S100A8/S100A9 Heterodimer

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and DTT.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

observed molecular weight :

7 kDa and 12 kDa, reducing conditions

theoretical molecular weight :

10 kDa (S100A8), 13 kDa (S100A9)

details of functionality :

Measured by its ability to induce IL-6 secretion by A375 human melanoma cells. Hibino, T. et al . (2013) Cancer Res. 73 :172. The ED50 for this effect is 1.5-6 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Mouse S100A8/S100A9 Heterodimer Protein Bioactivity

applications :

Bioactivity

source long :

E. coli -derived mouse S100A8/S100A9 Heterodimer protein Mouse S100A8 (Pro2-Glu89) Accession # P27005 Mouse S100A9 (Ala2-Lys113) Accession # P31725 N-terminus C-terminus

source short :

E. coli

USD :

432 USD

alt names :

60B8AG, CAGA, calgranulin A, Calgranulin B, Calprotectin, Calprotectin L1L subunit, CFAG, CGLA, CP-10, Cystic fibrosis antigen, L1AG, Leukocyte L1 complex light chain, MA387, MIF, Migration inhibitory factor-related protein 8, MRP-14, MRP8, NIF, p8, protein S100-A8, S100-A8, Urinary stone protein band A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.