Recombinant Human Mer Fc Chimera Protein, CF | R&D Systems 891-MR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Mer Fc Chimera Protein, CF

catalog :

891-MR-100

quantity :

100 ug

price :

428 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Wanke F, Gutbier S, Rümmelin A, Steinberg M, Hughes L, Koenen M, et al. Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages. Cell Death Dis. 2021;12:538 pubmed publisher
Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
Zizzo G, Hilliard B, Monestier M, Cohen P. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol. 2012;189:3508-20 pubmed
Cerchia L, Esposito C, Camorani S, Rienzo A, Stasio L, Insabato L, et al. Targeting Axl with an high-affinity inhibitory aptamer. Mol Ther. 2012;20:2291-303 pubmed publisher
Uehara H, Shacter E. Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells. J Immunol. 2008;180:2522-30 pubmed

product information

brand :

R&D Systems

master code :

891-MR

SKU :

891-MR-100

product name :

Recombinant Human Mer Fc Chimera Protein, CF

description :

The Recombinant Human Mer Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human Mer Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Mer

category :

Proteins and Enzymes

sizes available :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

100-110 kDa, reducing conditions

theoretical molecular weight :

78 kDa (monomer)

gene symbol :

MERTK

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human (rh) Mer Fc Chimera at 10 µg/mL (100 µL/well) can bind rhGas6 (Catalog # 885-GSB ) with a linear range of 0.03-1 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

AAB60430.1

applications :

Binding Activity

source :

Sf 21 (baculovirus)-derived Recombinant Human Mer Fc Chimera Protein, CF

USD :

421

USD 2023 :

428 USD

alt names :

c-Eyk, C-mer, c-mer proto-oncogene tyrosine kinase, EC 2.7.10, EC 2.7.10.1, MER, MER receptor tyrosine kinase, MerTK, MGC133349, Receptor tyrosine kinase MerTK, RP38Proto-oncogene c-Mer, STK kinase, tyrosine-protein kinase Mer

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage