product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Fc gamma RIIIA/CD16a (V176F) Protein, CF
catalog :
8894-FC-050
quantity :
50 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Kitanaga Y, Yamajuku D, Kubo S, Nakamura K, Maeda M, Seki M, et al. Discovery of a novel Igβ and FcγRIIB cross-linking antibody, ASP2713, and its potential application in the treatment of systemic lupus erythematosus. Int Immunopharmacol. 2021;101:108343 pubmed publisher
Zhang X, Olsen H, Chen S, So E, Zhou H, Burch E, et al. Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease. J Immunol. 2016;196:1165-76 pubmed publisher
product information
master code :
8894-FC
SKU :
8894-FC-050
product name :
Recombinant Human Fc gamma RIIIA/CD16a (V176F) Protein, CF
unit size :
50 ug
description :
The Recombinant Human Fc gamma RIIIA/CD16a (V176F) Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human Fc gamma RIIIA/CD16a (V176F) Protein, CF has been validated for the following applications: Bioactivity.
target :
Fc gamma RIIIA/CD16a
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in sterile PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
43-58 kDa, reducing conditions
theoretical molecular weight :
23 kDa
gene symbol :
FCGR3A
details of functionality :
Measured by its binding ability in a functional ELISA. When Recombinant Human Fc gamma RIIIa/CD16a (V176F) was immobilize on a Ms x PolyHis coated plate, it binds biotinylated Human IgG. The concentration of biotinylated Human IgG that produces 50% of the optimal binding response is approximately 0.5-2.5 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human Fc gamma RIIIA/CD16a (V176F) Protein Binding Activity
accessionNumbers :
P08637
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived human Fc gamma RIIIA/CD16a protein Gly17-Gln208, with a C-terminal 6-His tag
source short :
HEK293
extended description :
Low-affinity V176F polymorphic variant
USD :
432 USD
product details :
Low-affinity V176F polymorphic variant
alt names :
CD16a, CD16a antigen, CD16FCRIIIA, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG, low affinity IIIa, receptor for (CD16), Fc gamma receptor III-A, FCG3, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIIIa, Fc-gamma RIII-alpha, FCGR3, FCGR3A, FCGRIII, FcgRIIIA, FCR-10, FcRIII, FcRIIIa, IGFR3FcgammaRIIIA, immunoglobulin G Fc receptor III, low affinity III, receptor for (CD16), low affinity immunoglobulin gamma Fc region receptor III-A, neutrophil-specific antigen NA
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.