This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Lymphotoxin alpha1/beta2 Protein
catalog :
8884-LY-025
quantity :
25 ug
price :
567 USD
citations: 9
Reference
Liu S, Hulsman M, Leyendecker P, Chang E, Donovan K, Strobel F, et al. SMAC mimetics induce human macrophages to phagocytose live cancer cells. bioRxiv. 2024;: pubmed publisher
Sylvestre M, Barbier N, Sibut V, Nayar S, Monvoisin C, Léonard S, et al. KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties. Sci Adv. 2023;9:eadh2708 pubmed publisher
George J, Oittinen M, Martin Diaz L, Zapilko V, Iqbal S, Rintakangas T, et al. Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development. Cell Mol Gastroenterol Hepatol. 2021;12:873-889 pubmed publisher
Maksymowicz M, Miaczynska M, Banach Orłowska M. Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor. Cell Commun Signal. 2020;18:176 pubmed publisher
da Silva Antunes R, Mehta A, Madge L, Tocker J, Croft M. TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β. Front Immunol. 2018;9:576 pubmed publisher
Hähnlein J, Nadafi R, de Jong T, Ramwadhdoebe T, Semmelink J, Maijer K, et al. Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis. Arthritis Res Ther. 2018;20:35 pubmed publisher
Kanaya T, Sakakibara S, Jinnohara T, Hachisuka M, Tachibana N, Hidano S, et al. Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling. J Exp Med. 2018;215:501-519 pubmed publisher
Quach H, Kondo T, Watanabe M, Tamura R, Yajima Y, Sayama S, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor ?B Subunit RelB in Response to a Lymphotoxin ? Stimulation. Biol Pharm Bull. 2017;40:1669-1677 pubmed publisher
Nayar S, Campos J, Chung M, Navarro Núñez L, Chachlani M, Steinthal N, et al. Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures. J Immunol. 2016;197:1957-67 pubmed publisher
product information
master code :
8884-LY
SKU :
8884-LY-025
product name :
Recombinant Human Lymphotoxin alpha1/beta2 Protein
unit size :
25 ug
description :
The Recombinant Human Lymphotoxin alpha1/beta2 Protein from R&D Systems is derived from HEK293. The Recombinant Human Lymphotoxin alpha1/beta2 Protein has been validated for the following applications: Bioactivity.
target :
Lymphotoxin
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
65-76 kDa, reducing conditions
theoretical molecular weight :
61 kDa
gene symbol :
LTA
details of functionality :
Measured by its ability to induce IL-8 secretion by A375 human melanoma cells. The ED50 for this effect is 3-15 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
P01374 (rhLT alpha ), Q06643 (rhLT▀) Q06643 (rhLT▀)
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived human Lymphotoxin protein rhLT alpha (Leu35-Leu205) Accession # P01374 GGGGS rhLT▀ (Gln49-Gly244) Accession # Q06643 GGGGS rhLT▀ (Gln49-Gly244) Accession # Q06643 N-terminus C-terminus
source short :
HEK293
extended description :
Defined heterotrimer stoichiometry
USD :
567 USD
product details :
Defined heterotrimer stoichiometry
alt names :
LT, LTA, LTB, Lymphotoxin alpha, Lymphotoxinalpha, tnfb, TNF-beta, TNFSF1, TNFSF1B, TNFSF3, TNLG1E
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.