product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Lymphotoxin alpha1/beta2 Protein, CF
catalog :
8884-LY-025/CF
quantity :
25 ug
price :
567 USD
more info or order :
R&D Systems product webpage
citations: 7
Reference
George J, Oittinen M, Martin Diaz L, Zapilko V, Iqbal S, Rintakangas T, et al. Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development. Cell Mol Gastroenterol Hepatol. 2021;12:873-889 pubmed publisher
Maksymowicz M, Miaczynska M, Banach Orłowska M. Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor. Cell Commun Signal. 2020;18:176 pubmed publisher
da Silva Antunes R, Mehta A, Madge L, Tocker J, Croft M. TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β. Front Immunol. 2018;9:576 pubmed publisher
Hähnlein J, Nadafi R, de Jong T, Ramwadhdoebe T, Semmelink J, Maijer K, et al. Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis. Arthritis Res Ther. 2018;20:35 pubmed publisher
Kanaya T, Sakakibara S, Jinnohara T, Hachisuka M, Tachibana N, Hidano S, et al. Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling. J Exp Med. 2018;215:501-519 pubmed publisher
Quach H, Kondo T, Watanabe M, Tamura R, Yajima Y, Sayama S, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor ?B Subunit RelB in Response to a Lymphotoxin ? Stimulation. Biol Pharm Bull. 2017;40:1669-1677 pubmed publisher
Nayar S, Campos J, Chung M, Navarro Núñez L, Chachlani M, Steinthal N, et al. Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures. J Immunol. 2016;197:1957-67 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
8884-LY/CF
SKU :
8884-LY-025/CF
product name :
Recombinant Human Lymphotoxin alpha1/beta2 Protein, CF
description :
The Recombinant Human Lymphotoxin alpha1/beta2 Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human Lymphotoxin alpha1/beta2 Protein, CF has been validated for the following applications: Bioactivity.
target :
Lymphotoxin
unit size :
25 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
65-76 kDa, reducing conditions
theoretical molecular weight :
61 kDa
gene symbol :
LTA
details of functionality :
Measured by its ability to induce IL-8 secretion by A375 human melanoma cells. The ED50 for this effect is 3-15 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P01374 (rhLT alpha ), Q06643 (rhLTß) Q06643 (rhLTß)
applications :
Bioactivity
product keywords :
8884-LY, rhLTa1/b2, hLTa1/b2, carrier-free, carrier free, 8884LY/CF, cytokinegrowthfact, Lymphotoxin alpha2/beta1, Lymphotoxin alpha1/beta2, cytokine, cytokines, LTA, LTB
source :
HEK293-derived Recombinant Human Lymphotoxin alpha1/beta2 Protein, CF
extended description :
Defined heterotrimer stoichiometry
USD :
550
USD 2025 :
567 USD
product details :
Defined heterotrimer stoichiometry
alt names :
LT, LTA, LTB, Lymphotoxin alpha, Lymphotoxinalpha, tnfb, TNF-beta, TNFSF1, TNFSF1B, TNFSF3, TNLG1E
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.