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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IL-21 Protein
catalog :
8879-IL-010
quantity :
10 ug (also 50 ug)
price :
298 USD
more info or order :
citations: 26
Reference
Vaikunthanathan T, Landmann E, Correa D, Romano M, Trevelin S, Peng Q, et al. Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease. EBioMedicine. 2023;95:104778 pubmed publisher
Tate T, Matsumoto S, Nemoto K, Leisegang M, Nagayama S, Obama K, et al. Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3. Cancers (Basel). 2023;15: pubmed publisher
Cao L, Ma X, Zhang J, Yang M, He Z, Yang C, et al. CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response. Cell Transplant. 2023;32:9636897221149444 pubmed publisher
Asashima H, Mohanty S, Comi M, Ruff W, Hoehn K, Wong P, et al. PD-1highCXCR5-CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection. Cell Rep. 2023;42:111895 pubmed publisher
Gong Y, Shao H, Li Y, Brafford P, Stine Z, Sun J, et al. Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells. Cancer Res Commun. 2022;2:842-856 pubmed publisher
Nishio A, Hasan S, Park H, Park N, Salas J, Salinas E, et al. Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C. Nat Commun. 2022;13:5446 pubmed publisher
Rode A, Buus T, Mraz V, Al Jaberi F, Lopez D, Ford S, et al. Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor. Cells. 2022;11: pubmed publisher
Michaels Y, Edgar J, Major M, Castle E, Zimmerman C, Yin T, et al. DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells. Sci Adv. 2022;8:eabn5522 pubmed publisher
Piotrowska K, Słuczanowska Głąbowska S, Kurzawski M, Dziedziejko V, Kopytko P, Paczkowska E, et al. Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid Arthritis. Biomolecules. 2020;10: pubmed publisher
Higashioka K, Ota Y, Maehara T, Moriyama M, Ayano M, Mitoma H, et al. Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease. BMC Immunol. 2020;21:31 pubmed publisher
Gan H, Shen T, Chupp D, Taylor J, Sanchez H, Li X, et al. B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response. Sci Adv. 2020;6:eaay2793 pubmed publisher
Franke F, Kirchenbaum G, Kuerten S, Lehmann P. IL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B Cells. Cells. 2020;9: pubmed publisher
Xu R, Shears R, Sharma R, Krishna M, Webb C, Ali R, et al. IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue. Mucosal Immunol. 2020;13:460-470 pubmed publisher
Kraaijeveld R, Li Y, Yan L, de Leur K, Dieterich M, Peeters A, et al. Inhibition of T Helper Cell Differentiation by Tacrolimus or Sirolimus Results in Reduced B-Cell Activation: Effects on T Follicular Helper Cells. Transplant Proc. 2019;51:3463-3473 pubmed publisher
Blevins L, Zhou J, Crawford R, Kaminski N. TCDD-mediated suppression of naïve human B cell IgM secretion involves aryl hydrocarbon receptor-mediated reduction in STAT3 serine 727 phosphorylation and is restored by interferon-γ. Cell Signal. 2020;65:109447 pubmed publisher
Patrick A, Wang W, Brokamp E, Graham T, Aune T, Duis J. Juvenile idiopathic arthritis associated with a mutation in GATA3. Arthritis Res Ther. 2019;21:156 pubmed publisher
Dalloul I, Boyer F, Dalloul Z, Pignarre A, Caron G, Fest T, et al. Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissues. PLoS Genet. 2019;15:e1007721 pubmed publisher
Hung K, Woo Y, Lin I, Liu C, Wang L, Chen H, et al. The KDM4A/KDM4C/NF-κB and WDR5 epigenetic cascade regulates the activation of B cells. Nucleic Acids Res. 2018;46:5547-5560 pubmed publisher
Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod R, Drexler H. Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma. Oncotarget. 2018;9:14338-14353 pubmed publisher
Kato T, Matsuda T, Ikeda Y, Park J, Leisegang M, Yoshimura S, et al. Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells. Oncotarget. 2018;9:11009-11019 pubmed publisher
Geng J, Yu S, Zhao H, Sun X, Li X, Wang P, et al. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol. 2017;18:800-812 pubmed publisher
Zan H, Tat C, Qiu Z, Taylor J, Guerrero J, Shen T, et al. Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination. Nat Commun. 2017;8:14244 pubmed publisher
van Keimpema M, Grüneberg L, Schilder Tol E, Oud M, Beuling E, Hensbergen P, et al. The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells. Haematologica. 2017;102:573-583 pubmed publisher
Canavan J, Scotta C, Vossenkamper A, Goldberg R, Elder M, Shoval I, et al. Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease. Gut. 2016;65:584-94 pubmed publisher
Kofler D, Marson A, Dominguez Villar M, Xiao S, Kuchroo V, Hafler D. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest. 2014;124:2513-22 pubmed publisher
Wong T, Doyle A, Lee J, Jelinek D. Eosinophils regulate peripheral B cell numbers in both mice and humans. J Immunol. 2014;192:3548-58 pubmed publisher
image
image 1 :
R&D Systems 8879-IL-010 image 1
Recombinant Human IL-21 Protein Bioactivity
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
8879-IL
SKU :
8879-IL-010
product name :
Recombinant Human IL-21 Protein
description :
The Recombinant Human IL-21 Protein from R&D Systems is derived from E. coli. The Recombinant Human IL-21 Protein has been validated for the following applications: Bioactivity.
target :
IL-21
unit size :
10 ug (also 50 ug)
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.
observed molecular weight :
17 kDa, reducing conditions
theoretical molecular weight :
15 kDa
gene symbol :
IL21
details of functionality :
Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is <= 8 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9HBE4.3
applications :
Bioactivity
product keywords :
8879-IL, rhIL-21, hIL-21,, 8879IL, cytokinegrowthfact, IL21, IL 21, Interleukin 21, Interleukin-21, cytokine, cytokines, Th17, CVID11, Za11
source :
E. coli-derived Recombinant Human IL-21 Protein
extended description :
Analyzed by SEC-MALS
USD :
283
USD 2025 :
298 USD
product details :
Analyzed by SEC-MALS
alt names :
CVID11, IL21, IL-21Za11interleukin-21, interleukin 21, interleukin-21 isoform, Za11
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.