Recombinant Mouse LIF Protein | R&D Systems 8878-LF-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse LIF Protein

catalog :

8878-LF-025

quantity :

25 ug

price :

322 USD

citations: 18

Reference
Malla S, Martinez Gamero C, Kumari K, Achour C, Mermelekas G, Martinez Delgado D, et al. Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells. Sci Rep. 2024;14:28495 pubmed publisher
Malcore R, Samanta M, Kalantry S, Iwase S. Regulation of Sex-biased Gene Expression by the Ancestral X-Y Chromosomal Gene Pair Kdm5c-Kdm5d. bioRxiv. 2024;: pubmed publisher
Malla S, Kumari K, Garc xed a Prieto C, Caroli J, Nordin A, Phan T, et al. The scaffolding function of LSD1 controls DNA methylation in mouse ESCs. Nat Commun. 2024;15:7758 pubmed publisher
Gogoi M, Clark P, Ferreira A, Rodriguez Rodriguez N, Heycock M, Ko M, et al. ILC2-derived LIF licences progress from tissue to systemic immunity. Nature. 2024;632:885-892 pubmed publisher
Donahue K, Watkoske H, Kadiyala P, Du W, Brown K, Scales M, et al. Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth. Cancer Discov. 2024;14:1964-1989 pubmed publisher
Bilgic S, Domaniku A, Toledo B, Agca S, Weber B, Arabaci D, et al. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia. Nature. 2023;617:827-834 pubmed publisher
Graça F, Rai M, Hunt L, Stephan A, Wang Y, Gordon B, et al. The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy. Nat Commun. 2022;13:2370 pubmed publisher
Kelava I, Chiaradia I, Pellegrini L, Kalinka A, Lancaster M. Androgens increase excitatory neurogenic potential in human brain organoids. Nature. 2022;602:112-116 pubmed publisher
Noh K, Lee H, Choi T, Joo Y, Kim S, Kim H, et al. Negr1 controls adult hippocampal neurogenesis and affective behaviors. Mol Psychiatry. 2019;: pubmed publisher
Tang Y, Xiong S, Yu P, Liu F, Cheng L. Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210. Cell Rep. 2018;24:1355-1362.e3 pubmed publisher
Wang Y, Ma S, Chen Q, Jiao D, Yang Y. In vivo selection with lentiviral expression of Bcl2T69A/S70A/S87A mutant in hematopoietic stem cell-transplanted mice. Gene Ther. 2018;25:220-233 pubmed publisher
Du J, Wang X, Zhang X, Zhang X, Jiang H. DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway. Mol Med Rep. 2017;: pubmed publisher
Yang J, Wu C, Stefănescu I, Horowitz A. Analysis of Retinoic Acid-induced Neural Differentiation of Mouse Embryonic Stem Cells in Two and Three-dimensional Embryoid Bodies. J Vis Exp. 2017;: pubmed publisher
Mata Miranda M, Vazquez Zapien G, Rojas Lopez M, Sánchez Monroy V, Pérez Ishiwara D, Delgado Macuil R. Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells. Biol Res. 2017;50:14 pubmed publisher
Valenti G, Quinn H, Heynen G, Lan L, Holland J, Vogel R, et al. Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors. Cancer Res. 2017;77:2134-2147 pubmed publisher
Jiang D, Du J, Zhang X, Zhou W, Zong L, Dong C, et al. miR-124 promotes the neuronal differentiation of mouse inner ear neural stem cells. Int J Mol Med. 2016;38:1367-1376 pubmed publisher
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher
Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, et al. Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer Res. 2016;76:3884-94 pubmed publisher

product information

master code :

8878-LF

SKU :

8878-LF-025

product name :

Recombinant Mouse LIF Protein

unit size :

25 ug

description :

The Recombinant Mouse LIF Protein from R&D Systems is derived from E. coli. The Recombinant Mouse LIF Protein has been validated for the following applications: Bioactivity.

target :

LIF

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE with silver staining.

species :

Mouse

observed molecular weight :

20 kDa, reducing conditions

theoretical molecular weight :

20 kDa

gene symbol :

Lif

details of functionality :

Measured by its ability to induce IL-6 secretion by M1 mouse myeloid leukemia cells. The ED50 for this effect is 0.1-0.6 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Mouse LIF Promotes the Expansion of Mouse Embryonic Stem Cells.

accessionNumbers :

P09056

applications :

Bioactivity

source long :

E. coli -derived mouse LIF protein Pro25-Phe203

source short :

E. coli

USD :

322 USD

alt names :

CDF, D factor, DIA, differentiation inhibitory activity, differentiation stimulating factor, Differentiation-stimulating factor, Emfilermin, HILDA, HILDAcholinergic differentiation factor, leukemia inhibitory factor, leukemia inhibitory factor (cholinergic differentiation factor), Melanoma-derived LPL inhibitor, MLPLI

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.