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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse BAFF/BLyS/TNFSF13B Protein, CF
catalog :
8876-BF-010/CF
quantity :
10 ug
price :
271 USD
more info or order :
R&D Systems product webpage
citations: 27
Reference
Koizumi H, Fujii W, Sanjoba C, Goto Y. BAFF induces CXCR5 expression during B cell differentiation in bone marrow. Biochem Biophys Rep. 2023;34:101451 pubmed publisher
Kanemitsu Okada K, Abe M, Nakamura Y, Miyake T, Watanabe T, Yoshida O, et al. Role of B Cell-Activating Factor in Fibrosis Progression in a Murine Model of Non-Alcoholic Steatohepatitis. Int J Mol Sci. 2023;24: pubmed publisher
Satofuka H, Abe S, Moriwaki T, Okada A, Kazuki K, Tanaka H, et al. Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci. Nat Commun. 2022;13:1841 pubmed publisher
Liu L, Akkoyunlu M. Circulating CD138 enhances disease progression by augmenting autoreactive antibody production in a mouse model of systemic lupus erythematosus. J Biol Chem. 2021;297:101053 pubmed publisher
Kim J, Islam S, Qiao F, Singh A, Khan M, Won J, et al. Regulation of B cell functions by S-nitrosoglutathione in the EAE model. Redox Biol. 2021;45:102053 pubmed publisher
Chan C, Harley I, Pfluger P, Trompette A, Stankiewicz T, Allen J, et al. A BAFF/APRIL axis regulates obesogenic diet-driven weight gain. Nat Commun. 2021;12:2911 pubmed publisher
Tan C, Hiwa R, Mueller J, Vykunta V, Hibiya K, Noviski M, et al. NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting. Nat Immunol. 2020;21:1267-1279 pubmed publisher
Cai X, Zhu Y, Wang C, Tang X, Han L, Shu J, et al. Etanercept Inhibits B Cell Differentiation by Regulating TNFRII/TRAF2/NF-κB Signaling Pathway in Rheumatoid Arthritis. Front Pharmacol. 2020;11:676 pubmed publisher
Berry C, Liu X, Myles A, Nandi S, Chen Y, Hershberg U, et al. BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells. Cell Rep. 2020;31:107474 pubmed publisher
Ramezani Rad P, Leung C, Apgar J, Rickert R. E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells. J Immunol. 2020;204:1535-1542 pubmed publisher
Wu R, Lian W, Chen Y, Kuo C, Ke H, Hsieh C, et al. MicroRNA-29a Counteracts Glucocorticoid Induction of Bone Loss through Repressing TNFSF13b Modulation of Osteoclastogenesis. Int J Mol Sci. 2019;20: pubmed publisher
Ragonnaud E, Moritoh K, Bodogai M, Gusev F, Garaud S, Chen C, et al. Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis. Cancer Res. 2019;79:5826-5838 pubmed publisher
Jiang Y, Li C, Wu Q, An P, Huang L, Wang J, et al. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nat Commun. 2019;10:2935 pubmed publisher
Bolger Munro M, Choi K, Scurll J, Abraham L, Chappell R, Sheen D, et al. Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation. elife. 2019;8: pubmed publisher
Khoenkhoen S, Erikson E, Adori M, Stark J, Scholz J, Cancro M, et al. TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS. Immunol Cell Biol. 2019;97:485-497 pubmed publisher
Du S, Jacobs H, Arkatkar T, Rawlings D, Jackson S. Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells. J Immunol. 2018;201:3258-3268 pubmed publisher
Sang A, Danhorn T, Peterson J, Rankin A, O Connor B, Leach S, et al. Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus. Nat Commun. 2018;9:3973 pubmed publisher
Matsushita T, Kobayashi T, Mizumaki K, Kano M, Sawada T, Tennichi M, et al. BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance. Sci Adv. 2018;4:eaas9944 pubmed publisher
Schabla N, Perry G, Palmer V, Swanson P. VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation. J Immunol. 2018;201:930-939 pubmed publisher
Brightbill H, Suto E, Blaquiere N, Ramamoorthi N, Sujatha Bhaskar S, Gogol E, et al. NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nat Commun. 2018;9:179 pubmed publisher
de Riva A, Wallberg M, Ronchi F, Coulson R, Sage A, Thorne L, et al. Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment. PLoS ONE. 2017;12:e0181964 pubmed publisher
McKay J, Haro M, Daly C, Yammani R, Pang B, Swords W, et al. PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism. J Immunol. 2017;199:2020-2029 pubmed publisher
Park S, Sim H, Kim H, Jeong D, Wu G, Cho S, et al. CD11b regulates antibody class switching via induction of AID. Mol Immunol. 2017;87:47-59 pubmed publisher
Kuraoka M, Snowden P, Nojima T, Verkoczy L, Haynes B, Kitamura D, et al. BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. Cell Rep. 2017;18:1627-1635 pubmed publisher
Jellusova J, Cato M, Apgar J, Ramezani Rad P, Leung C, Chen C, et al. Gsk3 is a metabolic checkpoint regulator in B cells. Nat Immunol. 2017;18:303-312 pubmed publisher
Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, et al. Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation. J Immunol. 2017;198:1066-1080 pubmed publisher
Uslu K, Coleman A, Allman W, Katsenelson N, Bram R, Alugupalli K, et al. Impaired B cell receptor signaling is responsible for reduced TACI expression and function in X-linked immunodeficient mice. J Immunol. 2014;192:3582-95 pubmed publisher
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
8876-BF/CF
SKU :
8876-BF-010/CF
product name :
Recombinant Mouse BAFF/BLyS/TNFSF13B Protein, CF
Description :
The Recombinant Mouse BAFF/BLyS/TNFSF13B Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse BAFF/BLyS/TNFSF13B Protein, CF has been validated for the following applications: Bioactivity.
target :
BAFF/BLyS/TNFSF13B
category :
Proteins and Enzymes
unit size :
10 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in MOPS, NaCl and TCEP.
conjugate :
Unconjugated
purity :
>85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Mouse
observed molecular weight :
19-23 kDa (monomer) 38-47 kDa (non-reducible dimer), reducing conditions
theoretical molecular weight :
21 kDa
gene symbol :
Tnfsf13b
details of functionality :
Measured in a cell proliferation assay using anti-IgM stimulated mouse B cells. The ED50 for this effect is 0.1-0.5 ng/mL in the presence of goat anti-mouse IgM µ chain.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9WU72
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse BAFF/BLyS/TNFSF13B Protein
USD :
271 USD
alt names :
ApoL related ligand TALL-1, B lymphocyte stimulator, BAFFB-cell activating factor, B-cell-activating factor, BLyS, BLYSB-lymphocyte stimulator, CD257, CD257 antigen, Dendritic cell-derived TNF-like molecule, DTL, TALL1, TALL-1delta BAFF, TALL1Delta4 BAFF, THANK, TNF and ApoL-related leukocyte expressed ligand 1, TNF- and APOL-related leukocyte expressed ligand 1, TNF homolog that activates apoptosis, TNFSF13B, TNFSF20, tumor necrosis factor (ligand) superfamily, member 13b, tumor necrosis factor (ligand) superfamily, member 20, tumor necrosis factor ligand superfamily member 13B, tumor necrosis factor superfamily, member 13b, tumor necrosis factor-like protein ZTNF4, ZTNF4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.