Recombinant Human IGFBP-3 Protein, CF | R&D Systems 8874-B3-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IGFBP-3 Protein, CF

catalog :

8874-B3-025

quantity :

25 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 1

Reference
D Addio F, Maestroni A, Assi E, Ben Nasr M, Amabile G, Usuelli V, et al. The IGFBP3/TMEM219 pathway regulates beta cell homeostasis. Nat Commun. 2022;13:684 pubmed publisher

product information

master code :

8874-B3

SKU :

8874-B3-025

product name :

Recombinant Human IGFBP-3 Protein, CF

unit size :

25 ug

description :

The Recombinant Human IGFBP-3 Protein, CF from R&D Systems is derived from Sf 9 (baculovirus). The Recombinant Human IGFBP-3 Protein, CF has been validated for the following applications: Bioactivity.

target :

IGFBP-3

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE with silver staining

species :

Human

observed molecular weight :

34-41 kDa, reducing conditions

theoretical molecular weight :

29 kDa

gene symbol :

IGFBP3

details of functionality :

Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 0.03-0.15 ╡g/mL in the presence of 14 ng/mL Recombinant Human IGF-II (Catalog # 292-G2 ).

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P17936

applications :

Bioactivity

source long :

Spodoptera frugiperda , Sf 9 (baculovirus)-derived human IGFBP-3 protein Gly28-Lys291 Accession # P17936

source short :

Sf 9 (baculovirus)

extended description :

Sf 9 (baculovirus)-expressed

USD :

400 USD

product details :

Sf 9 (baculovirus)-expressed

alt names :

acid stable subunit of the 140 K IGF complex, binding protein 29, binding protein 53, growth hormone-dependent binding protein, IBP-3, IBP3BP-53, IGF-binding protein 3, IGFBP3, IGFBP-3, insulin-like growth factor binding protein 3, insulin-like growth factor-binding protein 3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage