This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human Gas6 Protein, CF
catalog :
885-GSB
quantity :
50 ug (also 500 ug)
price :
369 USD
citations: 19
Reference
Xue J, Xu L, Zhu H, Bai M, Li X, Zhao Z, et al. CD14+CD16- monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK. Arthritis Res Ther. 2020;22:221 pubmed publisher
Tutusaus A, de Gregorio E, Cucarull B, Cristóbal H, Aresté C, Graupera I, et al. A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target. Cell Mol Gastroenterol Hepatol. 2020;9:349-368 pubmed publisher
Azad T, Nouri K, Janse van Rensburg H, Maritan S, Wu L, Hao Y, et al. A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis. Oncogene. 2020;39:334-355 pubmed publisher
Hoj J, Mayro B, Pendergast A. A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. Cell Rep. 2019;29:3421-3434.e8 pubmed publisher
De Silva D, Zhang Z, Liu Y, Parker J, Xu C, Cai L, et al. Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. Sci Rep. 2019;9:18637 pubmed publisher
Strange D, Jiyarom B, Pourhabibi Zarandi N, Xie X, Baker C, Sadri Ardekani H, et al. Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells. MBio. 2019;10: pubmed publisher
Mills K, Quinn J, Roach S, Palisoul M, Nguyen M, Noia H, et al. p5RHH nanoparticle-mediated delivery of AXL siRNA inhibits metastasis of ovarian and uterine cancer cells in mouse xenografts. Sci Rep. 2019;9:4762 pubmed publisher
Sinik L, Minson K, Tentler J, Carrico J, Bagby S, Robinson W, et al. Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma. Mol Cancer Ther. 2019;18:278-288 pubmed publisher
Cheng L, Chen Y, Cheng A, Lee A, Cho C, Huang J, et al. AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells. J Biomed Sci. 2018;25:80 pubmed publisher
Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, et al. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nat Commun. 2018;9:433 pubmed publisher
Nidetz N, Gallagher T, Wiethoff C. Inhibition of type I interferon responses by adenovirus serotype-dependent Gas6 binding. Virology. 2018;515:150-157 pubmed publisher
Dantas Barbosa C, Lesluyes T, Loarer F, Chibon F, Treilleux I, Coindre J, et al. Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma. Br J Cancer. 2017;117:1787-1797 pubmed publisher
Cross S, Potter J, Aldo P, Kwon J, Pitruzzello M, Tong M, et al. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. J Immunol. 2017;199:2885-2895 pubmed publisher
Palisoul M, Quinn J, Schepers E, Hagemann I, Guo L, Reger K, et al. Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer. Mol Cancer Ther. 2017;16:2881-2891 pubmed publisher
Xu L, Chen Y, Dutra Clarke M, Mayakonda A, Hazawa M, Savinoff S, et al. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017;114:3981-3986 pubmed publisher
Kasikara C, Kumar S, Kimani S, Tsou W, Geng K, Davra V, et al. Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression. Mol Cancer Res. 2017;15:753-764 pubmed publisher
de Polo A, Luo Z, Gerarduzzi C, Chen X, Little J, Yuan Z. AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex. J Mol Cell Biol. 2017;9:154-165 pubmed publisher
Leconet W, Chentouf M, du Manoir S, Chevalier C, Sirvent A, Aït Arsa I, et al. Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis. Clin Cancer Res. 2017;23:2806-2816 pubmed publisher
Happonen K, Tran S, Mörgelin M, Prince R, Calzavarini S, Angelillo Scherrer A, et al. The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles. J Biol Chem. 2016;291:10586-601 pubmed publisher
product information
brand :
R&D Systems
master code :
885-GSB
SKU :
885-GSB-050
product name :
Recombinant Human Gas6 Protein, CF
description :
The Recombinant Human Gas6 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Gas6 Protein, CF has been validated for the following applications: Bioactivity.
target :
Gas6
category :
Proteins and Enzymes
unit size :
50 ug (also 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in Tris, NaCl and Citrate.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
70-85 kDa, reducing conditions
theoretical molecular weight :
70.5 kDa
gene symbol :
GAS6
details of functionality :
Measured by its ability to down regulate the expression of Axl in DU145 human prostate carcinoma cells. Mishra, A. et al . (2012) Mol. Cancer Res. 10 :703. The ED50 for this effect is 25-150 ng/mL
endotoxin note :
<1.0 EU per 1 µg of the protein by the LAL method.
catalog number base :
885-GSB
accessionNumbers :
NP_000811
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human Gas6 protein Ala49-Ala678, with a C-terminal 6-His tag
2020 USD :
349
2021 USD :
369 USD
alt names :
AXLLG, AXLLGAXL stimulatory factor, AXSFAXL receptor tyrosine kinase ligand, DKFZp666G247, FLJ34709, GAS-6, growth arrest-specific 6, growth arrest-specific protein 6
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.