Recombinant Human BID (Caspase-8-cleaved) Protein, CF | R&D Systems 882-B8-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human BID (Caspase-8-cleaved) Protein, CF

catalog :

882-B8-050

quantity :

50 ug

price :

468 USD

more info or order :

R&D Systems product webpage

citations: 8

Reference
Aublin Gex A, Jacolin F, Diaz O, Jacquemin C, Mar xe7 ais A, Walzer T, et al. Tethering of hexokinase 2 to mitochondria promotes resistance of liver cancer cells to natural killer cell cytotoxicity. Eur J Immunol. 2024;54:e2350954 pubmed publisher
Morishita H, Eguchi T, Tsukamoto S, Sakamaki Y, Takahashi S, Saito C, et al. Organelle degradation in the lens by PLAAT phospholipases. Nature. 2021;592:634-638 pubmed publisher
Spitz A, Zacharioudakis E, Reyna D, Garner T, Gavathiotis E. Eltrombopag directly inhibits BAX and prevents cell death. Nat Commun. 2021;12:1134 pubmed publisher
Guerra R, Bird G, Harvey E, Dharia N, Korshavn K, Prew M, et al. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Rep. 2018;24:3393-3403.e5 pubmed publisher
Andreu Fernández V, Sancho M, Genoves A, Lucendo E, Todt F, Lauterwasser J, et al. Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes. Proc Natl Acad Sci U S A. 2017;114:310-315 pubmed publisher
Lauterwasser J, Todt F, Zerbes R, Nguyen T, Craigen W, Lazarou M, et al. The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation. Sci Rep. 2016;6:32994 pubmed publisher
Shulga N, Pastorino J. Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. J Biol Chem. 2006;281:30824-33 pubmed
Liu F, Goff L, Hao J, Newland A, Jia L. Increase in the ratio of mitochondrial Bax/Bcl-XL induces Bax activation in human leukemic K562 cell line. Apoptosis. 2004;9:377-84 pubmed

product information

brand :

R&D Systems

master code :

882-B8

SKU :

882-B8-050

product name :

Recombinant Human BID (Caspase-8-cleaved) Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human BID (Caspase-8-cleaved) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human BID (Caspase-8-cleaved) Protein, CF has been validated for the following applications: Enzyme Activity.

target :

BID

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in HEPES-KOH and KCl.

conjugate :

Unconjugated

dilution :

Enzyme Activity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

9 kDa 14 kDa, reducing conditions

theoretical molecular weight :

7 kDa (N-terminal fragment) 15 kDa (C-terminal fragment)

gene symbol :

BID

details of functionality :

Measured by its ability to induce cytochromeác release from isolated mouse liver mitochondria using the Rat/Mouse Cytochrome c Quantikine ELISA (Catalog # MCTC0 ) to quantify cytochromeác. The typical EC50 for cytochrome c releasing activity is 50 nM. The EC50 for the desired application should be determined. Uncleaved Recombinant Human BID (Catalog # 846-BD ) is available.

accessionNumbers :

P55957

applications :

Enzyme Activity

source :

E. coli-derived Recombinant Human BID (Caspase-8-cleaved) Protein, CF

USD :

468 USD

alt names :

apoptic death agonist, BH3 interacting domain death agonist, BH3-interacting domain death agonist, BID isoform ES(1b), BID isoform L(2), BID isoform Si6, desmocollin type 4, FP497, Human BID coding sequence, MGC15319, MGC42355, p22 BID, tbid

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage