Recombinant Human IGFBP-6 Protein, CF | R&D Systems 876-B6 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IGFBP-6 Protein, CF

catalog :

876-B6

quantity :

25 ug

price :

339 USD

citations: 5

Reference
Chen Q, Qin S, Liu Y, Hong M, Qian C, Keller E, et al. IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker. Oncotarget. 2016;7:68140-68150 pubmed publisher
Zhu W, Wu Y, Cui C, Zhao H, Ba J, Chen H, et al. Expression of IGFBPâ€‘6 in proliferative vitreoretinopathy rat models and its effects on retinal pigment epithelialâ€‘J cells. Mol Med Rep. 2014;9:33-8 pubmed publisher
Barkho B, Song H, Aimone J, Smrt R, Kuwabara T, Nakashima K, et al. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006;15:407-21 pubmed
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed
Nakamura M, Miyamoto S, Maeda H, Ishii G, Hasebe T, Chiba T, et al. Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability. Biochem Biophys Res Commun. 2005;333:1011-6 pubmed

product information

brand :

R&D Systems

master code :

876-B6

SKU :

876-B6-025

product name :

Recombinant Human IGFBP-6 Protein, CF

description :

The Recombinant Human IGFBP-6 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IGFBP-6 Protein, CF has been validated for the following applications: Bioactivity.

target :

IGFBP-6

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

34 kDa, reducing conditions

theoretical molecular weight :

23 kDa

gene symbol :

IGFBP6

details of functionality :

Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 0.025-0.15 µg/mL in the presence of 14 ng/mL Recombinant Human IGF-II (Catalog # 292-G2 ).

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

876-B6

accessionNumbers :

NP_002169

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human IGFBP-6 protein Ala25-Gly240, with an N-terminal Met

2020 USD :

339

2021 USD :

339 USD

alt names :

IBP6, IBP-6, IGF binding protein 6, IGF-binding protein 6, IGFBP6, IGFBP-6, insulin-like growth factor binding protein 6, insulin-like growth factor-binding protein 6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, <= -20 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution.