Recombinant Human IGFBP-1 Protein, CF | R&D Systems 871-B1-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IGFBP-1 Protein, CF

catalog :

871-B1-025

quantity :

25 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 7

Reference
Han K, Singh K, Rodman M, Hassanzadeh S, Baumer Y, Huffstutler R, et al. Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness. Nutrients. 2021;13: pubmed publisher
Bak D, Choi M, Kim S, Lee B, Kim J, Jeon E, et al. Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth. Korean J Physiol Pharmacol. 2018;22:555-566 pubmed publisher
Lu J, Liu K, Schulz N, Karampelias C, Charbord J, Hilding A, et al. IGFBP1 increases ?-cell regeneration by promoting ?- to ?-cell transdifferentiation. EMBO J. 2016;35:2026-44 pubmed publisher
Wang X, Wei W, Krzeszinski J, Wang Y, Wan Y. A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption. Cell Metab. 2015;22:811-24 pubmed publisher
Borai A, Livingstone C, Mehta S, Zarif H, Abdelaal F, Ferns G. Biological variation in fasting serum insulin-like growth factor binding protein-1 (IGFBP-1) among individuals with a varying glucose tolerance. Clin Biochem. 2009;42:1270-4 pubmed publisher
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed
Nakamura M, Miyamoto S, Maeda H, Ishii G, Hasebe T, Chiba T, et al. Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability. Biochem Biophys Res Commun. 2005;333:1011-6 pubmed

product information

master code :

871-B1

SKU :

871-B1-025

product name :

Recombinant Human IGFBP-1 Protein, CF

unit size :

25 ug

description :

The Recombinant Human IGFBP-1 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IGFBP-1 Protein, CF has been validated for the following applications: Bioactivity.

target :

IGFBP-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

32 kDa, reducing conditions

theoretical molecular weight :

25 kDa

gene symbol :

IGFBP1

details of functionality :

Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is typically 0.1-0.6 ╡g/mL in the presence of 6 ng/mL recombinant human IGF-I.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P08833

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human IGFBP-1 protein Ala26-Asn259

source short :

NS0

USD :

400 USD

alt names :

alpha-pregnancy-associated endometrial globulin, amniotic fluid binding protein, binding protein-25, binding protein-26, binding protein-28, growth hormone independent-binding protein, hIGFBP-1, IBP1, IBP-1, IGF-binding protein 1, IGFBP1, IGFBP-1, IGF-BP25, insulin-like growth factor binding protein 1, insulin-like growth factor-binding protein 1, Placental protein 12, PP12AFBP

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage