Recombinant Human LBP Protein | R&D Systems 870-LP-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human LBP Protein

catalog :

870-LP-025

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 16

Reference
Hayashi K, Sano M, Kanayasu Toyoda T, Morita Y, Yamaguchi T, Ohya K, et al. Evaluation of the effect of cell freshness on pyrogen detection using a serum-free monocyte-activation test. PLoS ONE. 2024;19:e0316203 pubmed publisher
Lin Y, Kuo N, Shen H, Chang Y, Lin R, Liao T, et al. Prediction models combining zonulin, LPS, and LBP predict acute kidney injury and hepatorenal syndrome-acute kidney injury in cirrhotic patients. Sci Rep. 2023;13:13048 pubmed publisher
P xe9 rez Pons A, Jara Acevedo M, Henriques A, Navarro Navarro P, Garc xed a Montero A, xc1 lvarez Twose I, et al. Altered innate immune profile in blood of systemic mastocytosis patients. Clin Transl Allergy. 2022;12:e12167 pubmed publisher
Molinaro A, Koh A, Wu H, Schoeler M, Faggi M, Carreras A, et al. Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity. Mol Metab. 2020;37:100997 pubmed publisher
Hoogendijk A, Pourfarzad F, Aarts C, Tool A, Hiemstra I, Grassi L, et al. Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming. Cell Rep. 2019;29:2505-2519.e4 pubmed publisher
Higgins S, De Ceunynck K, Kellum J, Chen X, Gu X, Chaudhry S, et al. Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest. 2018;128:1471-1484 pubmed publisher
Lehmann R, Müller M, Klassert T, Driesch D, Stock M, Heinrich A, et al. Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells. Mucosal Immunol. 2018;11:627-642 pubmed publisher
Ding P, Darveau R, Wang C, Jin L. 3LPS-binding protein and its interactions with P. gingivalis LPS modulate pro-inflammatory response and Toll-like receptor signaling in human oral keratinocytes. PLoS ONE. 2017;12:e0173223 pubmed publisher
S Lashkari B, Anumba D. Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4. PLoS ONE. 2017;12:e0173646 pubmed publisher
Wensink A, Kok H, Meeldijk J, Fermie J, Froelich C, Hack C, et al. Granzymes A and K differentially potentiate LPS-induced cytokine response. Cell Death Discov. 2016;2:16084 pubmed publisher
Fang L, Xu Z, Wang G, Ji F, Mei C, Liu J, et al. Directed evolution of an LBP/CD14 inhibitory peptide and its anti-endotoxin activity. PLoS ONE. 2014;9:e101406 pubmed publisher
Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, et al. Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding. J Exp Med. 2014;211:1349-62 pubmed publisher
Cordeiro C, Esmaili H, Ansah G, Hincke M. Ovocalyxin-36 is a pattern recognition protein in chicken eggshell membranes. PLoS ONE. 2013;8:e84112 pubmed publisher
Malachowa N, Kobayashi S, Freedman B, Dorward D, Deleo F. Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps. J Immunol. 2013;191:6022-9 pubmed publisher
Gupta N, Li W, Willard B, Silverstein R, McIntyre T. Proteasome proteolysis supports stimulated platelet function and thrombosis. Arterioscler Thromb Vasc Biol. 2014;34:160-8 pubmed publisher
Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, et al. TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS ONE. 2011;6:e23132 pubmed publisher

product information

master code :

870-LP

SKU :

870-LP-025

product name :

Recombinant Human LBP Protein

unit size :

25 ug

description :

The Recombinant Human LBP Protein from R&D Systems is derived from NS0. The Recombinant Human LBP Protein has been validated for the following applications: Bioactivity.

target :

LBP

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris, NaCl and EDTA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

55-60 kDa, reducing conditions

theoretical molecular weight :

51 kDa

gene symbol :

LBP

details of functionality :

Measured by its ability to enhance LPS-stimulated IL-8 secretion by THP-1 human acute monocytic leukemia cells. The ED50 for this effect is 0.25-2.5 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAD21962

applications :

Bioactivity

source long :

Mouse myeloma cell line, NS0-derived human LBP protein Ala26-Val481

source short :

NS0

USD :

432 USD

alt names :

lipopolysaccharide binding protein, lipopolysaccharide-binding protein, LPS-binding protein, MGC22233

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage