product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human LBP Protein, CF
catalog :
870-LP-025/CF
quantity :
25 ug
price :
432 USD
more info or order :
R&D Systems product webpage
citations: 14
Reference
P xe9 rez Pons A, Jara Acevedo M, Henriques A, Navarro Navarro P, Garc xed a Montero A, xc1 lvarez Twose I, et al. Altered innate immune profile in blood of systemic mastocytosis patients. Clin Transl Allergy. 2022;12:e12167 pubmed publisher
Molinaro A, Koh A, Wu H, Schoeler M, Faggi M, Carreras A, et al. Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity. Mol Metab. 2020;37:100997 pubmed publisher
Hoogendijk A, Pourfarzad F, Aarts C, Tool A, Hiemstra I, Grassi L, et al. Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming. Cell Rep. 2019;29:2505-2519.e4 pubmed publisher
Higgins S, De Ceunynck K, Kellum J, Chen X, Gu X, Chaudhry S, et al. Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest. 2018;128:1471-1484 pubmed publisher
Lehmann R, Müller M, Klassert T, Driesch D, Stock M, Heinrich A, et al. Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells. Mucosal Immunol. 2018;11:627-642 pubmed publisher
Ding P, Darveau R, Wang C, Jin L. 3LPS-binding protein and its interactions with P. gingivalis LPS modulate pro-inflammatory response and Toll-like receptor signaling in human oral keratinocytes. PLoS ONE. 2017;12:e0173223 pubmed publisher
S Lashkari B, Anumba D. Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4. PLoS ONE. 2017;12:e0173646 pubmed publisher
Wensink A, Kok H, Meeldijk J, Fermie J, Froelich C, Hack C, et al. Granzymes A and K differentially potentiate LPS-induced cytokine response. Cell Death Discov. 2016;2:16084 pubmed publisher
Fang L, Xu Z, Wang G, Ji F, Mei C, Liu J, et al. Directed evolution of an LBP/CD14 inhibitory peptide and its anti-endotoxin activity. PLoS ONE. 2014;9:e101406 pubmed publisher
Canault M, Ghalloussi D, Grosdidier C, Guinier M, Perret C, Chelghoum N, et al. Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding. J Exp Med. 2014;211:1349-62 pubmed publisher
Cordeiro C, Esmaili H, Ansah G, Hincke M. Ovocalyxin-36 is a pattern recognition protein in chicken eggshell membranes. PLoS ONE. 2013;8:e84112 pubmed publisher
Malachowa N, Kobayashi S, Freedman B, Dorward D, Deleo F. Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps. J Immunol. 2013;191:6022-9 pubmed publisher
Gupta N, Li W, Willard B, Silverstein R, McIntyre T. Proteasome proteolysis supports stimulated platelet function and thrombosis. Arterioscler Thromb Vasc Biol. 2014;34:160-8 pubmed publisher
Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, et al. TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS ONE. 2011;6:e23132 pubmed publisher
product information
master code :
870-LP/CF
SKU :
870-LP-025/CF
product name :
Recombinant Human LBP Protein, CF
unit size :
25 ug
description :
The Recombinant Human LBP Protein, CF from R&D Systems is derived from NS0. The Recombinant Human LBP Protein, CF has been validated for the following applications: Bioactivity.
target :
LBP
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Tris, NaCl and EDTA.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
55-60 kDa, reducing conditions
theoretical molecular weight :
51 kDa
gene symbol :
LBP
details of functionality :
Measured by its ability to enhance LPS-stimulated IL-8 secretion by THP-1 human acute monocytic leukemia cells. The ED50 for this effect is 0.25-2.5 ng/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
AAD21962
applications :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived human LBP protein Ala26-Val481
source short :
NS0
extended description :
A New rh LBP is Now Available! The new protein has a His-tag!
USD :
432 USD
product details :
A New rh LBP is Now Available! The new protein has a His-tag!
alt names :
lipopolysaccharide binding protein, lipopolysaccharide-binding protein, LPS-binding protein, MGC22233
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.