Recombinant Human FCRN Protein, CF | R&D Systems 8639-FC product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FCRN Protein, CF

catalog :

8639-FC

quantity :

50 ug

price :

339 USD

citations: 2

Reference
Nicolaides N, Schweizer C, Somers E, Wang W, Fernando S, Ross E, et al. CA125 suppresses amatuximab immune-effector function and elevated serum levels are associated with reduced clinical response in first line mesothelioma patients. Cancer Biol Ther. 2018;19:622-630 pubmed publisher
Luo C, Chen S, Xu N, Wang C, Sai W, Zhao W, et al. Glycoengineering of pertuzumab and its impact on the pharmacokinetic/pharmacodynamic properties. Sci Rep. 2017;7:46347 pubmed publisher

product information

brand :

R&D Systems

master code :

8639-FC

SKU :

8639-FC-050

product name :

Recombinant Human FCRN Protein, CF

description :

The Recombinant Human FCRN Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human FCRN Protein, CF has been validated for the following applications: Bioactivity.

target :

FCRN/FCGRT

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

30-36 kDa (FCRN), 10 kDa ( beta 2 Microglobulin)

theoretical molecular weight :

31 kDa (FCRN), 10 kDa ( beta 2 Microglobulin)

gene symbol :

FCGRT

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human FCRN is immobilized at 2 µg/mL (100 µL/well), the concentration of biotinylated human IgG that produces 50% of the optimal binding response is approximately 2-10 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

8639-FC

accessionNumbers :

P55899

applications :

Bioactivity

source :

Human embryonic kidney cell, HEK293-derived human FCRN protein Ala24-Ser297, with a C-terminal 6-His tag

extended description :

Non-covalently associated with endogenous beta 2-Microglobulin

2020 USD :

339

2021 USD :

339 USD

product details :

Non-covalently associated with endogenous beta 2-Microglobulin

alt names :

alpha-chain, Fc fragment of IgG, receptor, transporter, alpha, FCGRT, FcRn, FcRn alpha chain, FCRNimmunoglobulin receptor, intestinal, heavy chain, IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, major histocompatibility complex class I-like Fc receptor, Neonatal Fc receptor, neonatal Fc-receptor for Ig

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.