Recombinant Human FCRN Protein, CF | R&D Systems 8639-FC-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human FCRN Protein, CF

catalog :

8639-FC-050

quantity :

50 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Ingle H, Molleston J, Hall P, Bui D, Wang L, Foster L, et al. The neonatal Fc receptor and DPP4 are human astrovirus receptors. bioRxiv. 2024;: pubmed publisher
Adhikari E, Lu P, Kang Y, McDonald A, Pruszynski J, Bates T, et al. Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy. bioRxiv. 2023;: pubmed publisher
Zekri L, Vogt F, Osburg L, M xfc ller S, Kauer J, Manz T, et al. An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer. EMBO Mol Med. 2021;13:e11902 pubmed publisher
Nicolaides N, Schweizer C, Somers E, Wang W, Fernando S, Ross E, et al. CA125 suppresses amatuximab immune-effector function and elevated serum levels are associated with reduced clinical response in first line mesothelioma patients. Cancer Biol Ther. 2018;19:622-630 pubmed publisher
Luo C, Chen S, Xu N, Wang C, Sai W, Zhao W, et al. Glycoengineering of pertuzumab and its impact on the pharmacokinetic/pharmacodynamic properties. Sci Rep. 2017;7:46347 pubmed publisher

product information

master code :

8639-FC

SKU :

8639-FC-050

product name :

Recombinant Human FCRN Protein, CF

unit size :

50 ug

description :

The Recombinant Human FCRN Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human FCRN Protein, CF has been validated for the following applications: Bioactivity.

target :

FCRN

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

30-36 kDa (FCRN), 10 kDa (▀2 Microglobulin)

theoretical molecular weight :

31 kDa (FCRN), 10 kDa (▀2 Microglobulin)

gene symbol :

FCGRT

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human FCRN is immobilized at 2 ╡g/mL (100 ╡L/well), the concentration of biotinylated human IgG that produces 50% of the optimal binding response is approximately 2-10 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P55899

applications :

Bioactivity

source long :

Human embryonic kidney cell, HEK293-derived human FCRN protein Ala24-Ser297, with a C-terminal 6-His tag

source short :

HEK293

extended description :

Analyzed by SEC-MALS. Non-covalently associated with endogenous beta 2-Microglobulin

USD :

432 USD

product details :

Analyzed by SEC-MALS. Non-covalently associated with endogenous beta 2-Microglobulin

alt names :

alpha-chain, Fc fragment of IgG, receptor, transporter, alpha, FCGRT, FcRn, FcRn alpha chain, FCRNimmunoglobulin receptor, intestinal, heavy chain, IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, major histocompatibility complex class I-like Fc receptor, Neonatal Fc receptor, neonatal Fc-receptor for Ig

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage