This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human VCAM-1/CD106 Fc Chimera Protein, CF
catalog :
862-VC
quantity :
100 ug
price :
365 USD
citations: 17
Reference
Natoni A, Farrell M, Harris S, Falank C, Kirkham McCarthy L, Macauley M, et al. Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model. Haematologica. 2019;: pubmed publisher
Karpova D, Rettig M, Ritchey J, Cancilla D, Christ S, Gehrs L, et al. Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells. J Clin Invest. 2019;129:2745-2759 pubmed publisher
Laufer J, Lyck R, Legler D. ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins. FASEB J. 2018;32:4824-4835 pubmed publisher
Petkau G, Kawano Y, Wolf I, Knoll M, Melchers F. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol. 2018;48:975-989 pubmed publisher
Stewart Hutchinson P, Szasz T, Jaeger E, Onken M, Cooper J, Morley S. Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate. J Leukoc Biol. 2017;102:941-948 pubmed publisher
Moslem M, Eggenschwiler R, Wichmann C, Buhmann R, Cantz T, Henschler R. Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells. Stem Cells Int. 2017;2017:7316354 pubmed publisher
Koutsogiannaki S, Schaefers M, Okuno T, Ohba M, Yokomizo T, Priebe G, et al. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci. 2017;156:402-411 pubmed publisher
Ta D, Guedens W, Vranken T, Vanschoenbeek K, Steen Redeker E, Michiels L, et al. Enhanced Biosensor Platforms for Detecting the Atherosclerotic Biomarker VCAM1 Based on Bioconjugation with Uniformly Oriented VCAM1-Targeting Nanobodies. Biosensors (Basel). 2016;6: pubmed publisher
Lozano M, Cook A, Bastida J, Paul D, Iruin G, Cid A, et al. Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction. Blood. 2016;128:1282-9 pubmed publisher
Mukovozov I, Huang Y, Zhang Q, Liu G, Siu A, Sokolskyy Y, et al. The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells. J Immunol. 2015;195:3334-44 pubmed publisher
Chakraborty S, Hu S, Wu S, Karmenyan A, Chiou A. The interaction affinity between vascular cell adhesion molecule-1 (VCAM-1) and very late antigen-4 (VLA-4) analyzed by quantitative FRET. PLoS ONE. 2015;10:e0121399 pubmed publisher
Mahadev V, Starr R, Wright S, Martinez C, Jensen M, Barish M, et al. Cytokine induction of VCAM-1 but not IL13R?2 on glioma cells: a tale of two antibodies. PLoS ONE. 2014;9:e95123 pubmed publisher
Chaar V, Laurance S, Lapoumeroulie C, Cochet S, De Grandis M, Colin Y, et al. Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation. J Biol Chem. 2014;289:11512-21 pubmed publisher
Huang J, Filipe A, Rahuel C, Bonnin P, Mesnard L, Guérin C, et al. Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice. Kidney Int. 2014;85:1123-36 pubmed publisher
Lee J, Sohn J, Ryu S, Hong C, Moon K, Park J. A novel human anti-VCAM-1 monoclonal antibody ameliorates airway inflammation and remodelling. J Cell Mol Med. 2013;17:1271-81 pubmed publisher
Chiang Y, Ho K, Sun C, Chiu J, Lee F, Liao F, et al. CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE. 2013;8:e61761 pubmed publisher
Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson S, Shulman Z, et al. Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol. 2007;8:1076-85 pubmed
product information
brand :
R&D Systems
master code :
862-VC
SKU :
862-VC-100
product name :
Recombinant Human VCAM-1/CD106 Fc Chimera Protein, CF
description :
The Recombinant Human VCAM-1/CD106 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human VCAM-1/CD106 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
VCAM-1/CD106
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
115-130 kDa, reducing conditions
theoretical molecular weight :
101.6 kDa (monomer)
gene symbol :
VCAM1
details of functionality :
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 104 cells/well are added to human VCAM-1 coated plates (10 µg/mL with 100 µL/well), approximately 90-100% will adhere after 1 hour incubation at RT. Optimal dilutions should be determined by each laboratory for each application.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
862-VC
accessionNumbers :
P19320
applications :
Bioactivity
source :
Mouse myeloma cell line, NS0-derived human VCAM-1/CD106 protein Met Human VCAM-1 (Phe25-Glu698) Accession # P19320 IEGRMD Human IgG1 (Pro100-Lys330) 6-His tag N-terminus C-terminus
2020 USD :
365
2021 USD :
365 USD
alt names :
CD106, CD106 antigen, DKFZp779G2333, INCAM-100, L1CAM, MGC99561, vascular cell adhesion molecule 1, vascular cell adhesion protein 1, V-CAM 1, VCAM1, VCAM-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.