Recombinant Human IL-35 Fc Chimera Protein, CF | R&D Systems 8608-IL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IL-35 Fc Chimera Protein, CF

catalog :

8608-IL-050

quantity :

50 ug

price :

400 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Feng J, Li K, Xie F, Han L, Wu Y. IL-35 ameliorates lipopolysaccharide-induced endothelial dysfunction by inhibiting endothelial-to-mesenchymal transition. Int Immunopharmacol. 2024;129:111567 pubmed publisher
Lombardelli L, Logiodice F, Kullolli O, Haller H, Agostinis C, Bulla R, et al. At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success. Int J Mol Sci. 2022;23: pubmed publisher
Xu R, Shears R, Sharma R, Krishna M, Webb C, Ali R, et al. IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue. Mucosal Immunol. 2020;13:460-470 pubmed publisher

product information

brand :

R&D Systems

master code :

8608-IL

SKU :

8608-IL-050

product name :

Recombinant Human IL-35 Fc Chimera Protein, CF

unit size :

50 ug

seo description :

The Recombinant Human IL-35 Fc Chimera Protein, CF from R&D Systems is derived from HEK293. The Recombinant Human IL-35 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

IL-35

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>80%, by SDS-PAGE under reducing conditions and visualized by silver stain.

species :

Human

observed molecular weight :

81-97 kDa, reducing conditions

theoretical molecular weight :

73 kDa

gene symbol :

EBI3

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Human IL-12 R▀2 Fc Chimera (Catalog # 1959-B2 ) is immobilized at 5 ╡g/mL (100 ╡L/well), the concentration of Recombinant Human IL-35 Fc Chimera that produces 50% optimal binding response is approximately 20-120 ng/mL.

endotoxin note :

<0.30 EU per 1 ╡g of the protein by the LAL method.

top caption :

Recombinant Human IL-35 Fc Chimera Protein Bioactivity

accessionNumbers :

Q14213 (IL-27▀/EBI3) P29459 (IL-12 alpha /p35)

applications :

Bioactivity

source :

HEK293-derived Recombinant Human IL-35 Fc Chimera Protein, CF

USD :

400 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage