Recombinant Mouse GDF-5 Protein | R&D Systems 853-G5-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse GDF-5 Protein

catalog :

853-G5-050

quantity :

50 ug

price :

491 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Tsutsumi H, Chiba T, Fujii Y, Matsushima T, Kimura T, Kanai A, et al. Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells. bioRxiv. 2024;: pubmed publisher
Zhao Y, Zhang M, Liu H, Wang J. Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptor type IB protects neurons against kainic acid-induced neurodegeneration. Neurosci Lett. 2017;651:36-42 pubmed publisher
Ayerst B, Smith R, Nurcombe V, Day A, Merry C, Cool S. Growth Differentiation Factor 5-Mediated Enhancement of Chondrocyte Phenotype Is Inhibited by Heparin: Implications for the Use of Heparin in the Clinic and in Tissue Engineering Applications. Tissue Eng Part A. 2017;23:275-292 pubmed publisher
Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G. Generation of articular chondrocytes from human pluripotent stem cells. Nat Biotechnol. 2015;33:638-45 pubmed publisher
Ratnayake M, Plöger F, Santibanez Koref M, Loughlin J. Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. PLoS ONE. 2014;9:e86590 pubmed publisher
Hinoi E, Nakamura Y, Takada S, Fujita H, Iezaki T, Hashizume S, et al. Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure. Diabetes. 2014;63:162-75 pubmed publisher
Zaidi S, Huang Q, Momen A, Riazi A, Husain M. Growth differentiation factor 5 regulates cardiac repair after myocardial infarction. J Am Coll Cardiol. 2010;55:135-43 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
Shimaoka H, Dohi Y, Ohgushi H, Ikeuchi M, Okamoto M, Kudo A, et al. Recombinant growth/differentiation factor-5 (GDF-5) stimulates osteogenic differentiation of marrow mesenchymal stem cells in porous hydroxyapatite ceramic. J Biomed Mater Res A. 2004;68:168-76 pubmed

product information

brand :

R&D Systems

master code :

853-G5

SKU :

853-G5-050

product name :

Recombinant Mouse GDF-5 Protein

unit size :

50 ug

seo description :

The Recombinant Mouse GDF-5 Protein from R&D Systems is derived from E. coli. The Recombinant Mouse GDF-5 Protein has been validated for the following applications: Bioactivity.

target :

GDF-5/BMP-14

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Mouse

theoretical molecular weight :

13.7 kDa (monomer)

gene symbol :

Gdf5

details of functionality :

Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al . (1999) Exp. Cell Res. 250 :351. The ED50 for this effect is 0.2-1.2 ╡g/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P43027

applications :

Bioactivity

source :

E. coli-derived Recombinant Mouse GDF-5 Protein

USD :

491 USD

alt names :

BMP14, BMP-14, Cartilage-derived morphogenetic protein 1, cartilage-derived morphogenetic protein-1, CDMP-1, CDMP1LAP4, GDF5, GDF-5, growth differentiation factor 5, growth/differentiation factor 5, OS5, Radotermin, SYNS2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage