Recombinant Human IFN-beta Protein | R&D Systems 8499-IF product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IFN-beta Protein

catalog :

8499-IF

quantity :

10 ug

price :

239 USD

citations: 15

Reference
Li D, Wu R, Guo W, Xie L, Qiao Z, Chen S, et al. STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production. Cell Rep. 2019;29:1249-1260.e4 pubmed publisher
Ginting T, Christian S, Larasati Y, Suryatenggara J, Suriapranata I, Mathew G. Antiviral interferons induced by Newcastle disease virus (NDV) drive a tumor-selective apoptosis. Sci Rep. 2019;9:15160 pubmed publisher
Guo W, Wei J, Zhong X, Zang R, Lian H, Hu M, et al. SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA. Cell Mol Immunol. 2019;: pubmed publisher
Good C, Wells A, Coyne C. Type III interferon signaling restricts enterovirus 71 infection of goblet cells. Sci Adv. 2019;5:eaau4255 pubmed publisher
Xu H, Xu S, Xie S, Zhang Y, Yang J, Zhang W, et al. MicroRNA-122 supports robust innate immunity in hepatocytes by targeting the RTKs/STAT3 signaling pathway. elife. 2019;8: pubmed publisher
An P, Sáenz Robles M, Duray A, Cantalupo P, Pipas J. Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence. PLoS Pathog. 2019;15:e1007505 pubmed publisher
Cañadas I, Thummalapalli R, Kim J, Kitajima S, Jenkins R, Christensen C, et al. Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses. Nat Med. 2018;24:1143-1150 pubmed publisher
Singanayagam A, Glanville N, Girkin J, Ching Y, Marcellini A, Porter J, et al. Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations. Nat Commun. 2018;9:2229 pubmed publisher
Holly M, Smith J. Adenovirus Infection of Human Enteroids Reveals Interferon Sensitivity and Preferential Infection of Goblet Cells. J Virol. 2018;92: pubmed publisher
Vougiouklakis T, Bao R, Nakamura Y, Saloura V. Protein methyltransferases and demethylases dictate CD8+ T-cell exclusion in squamous cell carcinoma of the head and neck. Oncotarget. 2017;8:112797-112808 pubmed publisher
Fang R, Wang C, Jiang Q, Lv M, Gao P, Yu X, et al. NEMO-IKK? Are Essential for IRF3 and NF-?B Activation in the cGAS-STING Pathway. J Immunol. 2017;199:3222-3233 pubmed publisher
Corry J, Arora N, Good C, Sadovsky Y, Coyne C. Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface. Proc Natl Acad Sci U S A. 2017;114:9433-9438 pubmed publisher
Dai X, Tohyama M, Murakami M, Sayama K. Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL)-1β and IL-18 release. Exp Dermatol. 2017;26:904-911 pubmed publisher
Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed publisher
Worthington J, Spain G, Timms J. Effects of ErbB2 Overexpression on the Proteome and ErbB Ligand-specific Phosphosignaling in Mammary Luminal Epithelial Cells. Mol Cell Proteomics. 2017;16:608-621 pubmed publisher

product information

brand :

R&D Systems

master code :

8499-IF

SKU :

8499-IF-010

product name :

Recombinant Human IFN-beta Protein

description :

The Recombinant Human IFN-beta Protein from R&D Systems is derived from CHO. The Recombinant Human IFN-beta Protein has been validated for the following applications: Bioactivity.

target :

IFN-beta

category :

Proteins and Enzymes

unit size :

10 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in Citric Acid and CHAPS with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE with silver staining.

species :

Human

observed molecular weight :

20-26 kDa, reducing conditions

theoretical molecular weight :

20 kDa

gene symbol :

IFNB1

details of functionality :

Measured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. Meager, A. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 129. The ED50 for this effect is 5-30 pg/mL. The specific activity of Recombinant Human IFN-beta is approximately 2.8 x 108 IU/mg, which is calibrated against human IFN-beta WHO International Standard (NIBSC code: 00/572).

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

catalog number base :

8499-IF

accessionNumbers :

P01574

applications :

Bioactivity

source :

Chinese Hamster Ovary cell line, CHO-derived human IFN-beta protein Met22-Asn187

extended description :

S.A approximately 2.8x10^8 IU/mg compared to WHO standard

2020 USD :

239

2021 USD :

239 USD

product details :

S.A approximately 2.8x10^8 IU/mg compared to WHO standard

alt names :

Fibroblast interferon, IFB, IFBIFNB, IFF, IFNB, IFNB1, IFNbeta, IFN-beta, interferon beta, interferon, beta 1, fibroblast, MGC96956

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.