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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IFN-beta Protein
catalog :
8499-IF-010
quantity :
10 ug
price :
286 USD
more info or order :
citations: 54
Reference
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Ma X, Wang Q, Sun C, Agarwal I, Wu H, Chen J, et al. Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis. Cell Rep. 2023;42:112944 pubmed publisher
Nigam N, Bernard B, Sevilla S, Kim S, Dar M, Tsai D, et al. SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck. Cell Rep. 2023;42:112823 pubmed publisher
Ta A, Ricci Azevedo R, Vasudevan S, Wright S, Kumari P, Havira M, et al. A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3. Nat Commun. 2023;14:2035 pubmed publisher
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Ng W, Kwek S, Sun B, Yousefi M, Ong E, Tan H, et al. A fast-growing dengue virus mutant reveals a dual role of STING in response to infection. Open Biol. 2022;12:220227 pubmed publisher
Kenaston M, Pham O, Petit M, Shah P. Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networks. BMC Genomics. 2022;23:787 pubmed publisher
Langbein L, Sementino E, Zhong Z, Jiang W, Li L, Testa J, et al. Data supporting the roles of BAP1, STING, and IFN-β in ISGF3 activation in ccRCC. Data Brief. 2022;45:108743 pubmed publisher
Furtado N, G xf3 mez M, de Mello I, Fernandes D, Bonaldo M. Phenotypic and Genetic Studies of the Viral Lineage Associated with the Recent Yellow Fever Outbreak in Brazil. Viruses. 2022;14: pubmed publisher
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Ka N, Lim G, Hwang S, Kim S, Lee M. IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer. Cell Rep. 2021;37:110138 pubmed publisher
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product information
master code :
8499-IF
SKU :
8499-IF-010
product name :
Recombinant Human IFN-beta Protein
unit size :
10 ug
description :
The Recombinant Human IFN-beta Protein from R&D Systems is derived from CHO. The Recombinant Human IFN-beta Protein has been validated for the following applications: Bioactivity.
target :
IFN-beta
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in Citric Acid and CHAPS with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE with silver staining.
species :
Human
observed molecular weight :
20-26 kDa, reducing conditions
theoretical molecular weight :
20 kDa
gene symbol :
IFNB1
details of functionality :
Measured in anti-viral assays using HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. Meager, A. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al . (eds): IRL Press. 129. The ED50 for this effect is 5.00-30.0 pg/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human IFN-beta Protein Binding Activity
accessionNumbers :
P01574
applications :
Bioactivity
source long :
Chinese Hamster Ovary cell line, CHO-derived human IFN-beta protein Met22-Asn187
source short :
CHO
USD :
286 USD
alt names :
Fibroblast interferon, IFB, IFBIFNB, IFF, IFNB, IFNB1, IFNbeta, IFN-beta, interferon beta, interferon, beta 1, fibroblast, MGC96956
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.