product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human TGF-beta 3 (CHO-expressed) Protein
catalog :
8420-B3-005
quantity :
5 ug (also 25 ug)
price :
237 USD
more info or order :
R&D Systems product webpage
citations: 12
Reference
Ideno H, Imaizumi K, Shimada H, Sanosaka T, Nemoto A, Kohyama J, et al. Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms. iScience. 2022;25:105140 pubmed publisher
Watanabe M, Buth J, Haney J, Vishlaghi N, Turcios F, Elahi L, et al. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports. 2022;17:2220-2238 pubmed publisher
Takahashi K, Podyma Inoue K, Saito M, Sakakitani S, Sugauchi A, Iida K, et al. TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3. Cell Rep. 2022;40:111411 pubmed publisher
Earley A, Burbulla L, Krainc D, Awatramani R. Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons. Sci Rep. 2021;11:22257 pubmed publisher
de Rus Jacquet A, Tancredi J, Lemire A, DeSantis M, Li W, O Shea E. The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson's disease. elife. 2021;10: pubmed publisher
Garnica Galvez S, Korntner S, Skoufos I, Tzora A, Diakakis N, Prassinos N, et al. Hyaluronic Acid as Macromolecular Crowder in Equine Adipose-Derived Stem Cell Cultures. Cells. 2021;10: pubmed publisher
de Rus Jacquet A. Preparation and Co-Culture of iPSC-Derived Dopaminergic Neurons and Astrocytes. Curr Protoc Cell Biol. 2019;85:e98 pubmed publisher
Roth S, Brehm W, Groß C, Scheibe P, Schubert S, Burk J. Transforming Growth Factor Beta 3-Loaded Decellularized Equine Tendon Matrix for Orthopedic Tissue Engineering. Int J Mol Sci. 2019;20: pubmed publisher
Ren J, Smid M, Iaria J, Salvatori D, van Dam H, Zhu H, et al. Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression. Breast Cancer Res. 2019;21:109 pubmed publisher
Wei X, Zhang L, Zhou Z, Kwon O, Zhang Y, Nguyen H, et al. Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell. 2019;24:753-768.e6 pubmed publisher
Sow H, Ren J, Camps M, Ossendorp F, Ten Dijke P. Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models. Cells. 2019;8: pubmed publisher
Roth S, Schubert S, Scheibe P, Groß C, Brehm W, Burk J. Growth Factor-Mediated Tenogenic Induction of Multipotent Mesenchymal Stromal Cells Is Altered by the Microenvironment of Tendon Matrix. Cell Transplant. 2018;27:1434-1450 pubmed publisher
image
image 1 :
R&D Systems 8420-B3-005 image 1
Recombinant Human TGF-beta 3 (CHO-expressed) Protein Bioactivity
product information
brand :
R&D Systems
master code :
8420-B3
SKU :
8420-B3-005
product name :
Recombinant Human TGF-beta 3 (CHO-expressed) Protein
description :
The Recombinant Human TGF-beta 3 (CHO-expressed) Protein from R&D Systems is derived from CHO. The Recombinant Human TGF-beta 3 (CHO-expressed) Protein has been validated for the following applications: Bioactivity.
target :
TGF-beta 3
category :
Proteins and Enzymes
unit sizes :
5 ug (also 25 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Human
observed molecular weight :
9-11 kDa, reducing conditions
theoretical molecular weight :
13 kDa
gene symbol :
TGFB3
details of functionality :
Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. Tsang, M. et al . (1995) Cytokine 7 :389. The ED50 for this effect is 0.01-0.04 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P10600
applications :
Bioactivity
source :
CHO-derived Recombinant Human TGF-beta 3 (CHO-expressed) Protein
USD :
237 USD
alt names :
ARVD, ARVD1, FLJ16571, LDS5, RNHF, TGFB3, TGFbeta 3, TGF-beta3, TGF-beta-3, transforming growth factor beta-3, transforming growth factor, beta 3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.