Recombinant Mouse FGF-21 Protein | R&D Systems 8409-FG-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse FGF-21 Protein

catalog :

8409-FG-025

quantity :

25 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Yanucil C, Kentrup D, Li X, Grabner A, Schramm K, Martinez E, et al. FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes. Sci Rep. 2022;12:7326 pubmed publisher
Higgins C, Mayer A, Zhang Y, Franczyk M, Ballentine S, Yoshino J, et al. SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase. Nat Commun. 2022;13:1074 pubmed publisher
Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, et al. PPARγ and PPARα synergize to induce robust browning of white fat in vivo. Mol Metab. 2020;36:100964 pubmed publisher
Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, et al. Peripherally derived FGF21 promotes remyelination in the central nervous system. J Clin Invest. 2017;127:3496-3509 pubmed publisher
Zhang J, Gupte J, Gong Y, Weiszmann J, Zhang Y, Lee K, et al. Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action. EBioMedicine. 2017;15:173-183 pubmed publisher
Dunshee D, Bainbridge T, Kljavin N, Zavala Solorio J, Schroeder A, Chan R, et al. Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21. J Biol Chem. 2016;291:5986-96 pubmed publisher

image

image 1 :

FGF-21 Stimulates Cell Proliferation.

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

8409-FG

SKU :

8409-FG-025

product name :

Recombinant Mouse FGF-21 Protein

Description :

The Recombinant Mouse FGF-21 Protein from R&D Systems is derived from NS0. The Recombinant Mouse FGF-21 Protein has been validated for the following applications: Bioactivity.

target :

FGF-21

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4 and EDTA with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Mouse

observed molecular weight :

22-25 kDa, reducing conditions

theoretical molecular weight :

20 kDa

gene symbol :

Fgf21

details of functionality :

Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.4-2 µg/mL in the presence of Recombinant Mouse Klotho beta (Catalog # 2619-KB ).

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q9JJN1

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse FGF-21 Protein

USD :

423 USD

alt names :

FGF21, FGF-21, fibroblast growth factor 21

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage