Recombinant Human 4-1BB/TNFRSF9 Fc Chimera Protein, CF | R&D Systems 838-4B-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human 4-1BB/TNFRSF9 Fc Chimera Protein, CF

catalog :

838-4B-100

quantity :

100 ug

price :

377 USD

more info or order :

R&D Systems product webpage

citations: 5

Reference
Weigand K, Peschel G, Grimm J, Luu K, Schacherer D, Wiest R, et al. Soluble CD137 is a novel serum marker of liver cirrhosis in patients with hepatitis C and alcohol-associated disease etiology. Eur J Immunol. 2022;52:633-645 pubmed publisher
Harfuddin Z, Dharmadhikari B, Wong S, Duan K, Poidinger M, Kwajah S, et al. Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype. Sci Rep. 2016;6:29712 pubmed publisher
Harfuddin Z, Kwajah S, Chong Nyi Sim A, MacAry P, Schwarz H. CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses. Oncoimmunology. 2013;2:e26859 pubmed
Moh M, Lorenzini P, Gullo C, Schwarz H. Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling. FASEB J. 2013;27:2957-66 pubmed publisher
Maniar A, Zhang X, Lin W, Gastman B, Pauza C, Strome S, et al. Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement. Blood. 2010;116:1726-33 pubmed publisher

product information

brand :

R&D Systems

master code :

838-4B

SKU :

838-4B-100

product name :

Recombinant Human 4-1BB/TNFRSF9 Fc Chimera Protein, CF

description :

The Recombinant Human 4-1BB/TNFRSF9 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human 4-1BB/TNFRSF9 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

4-1BB/TNFRSF9/CD137

category :

Proteins and Enzymes

sizes available :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Human

observed molecular weight :

50-65 kDa, reducing conditions

theoretical molecular weight :

44.8 kDa (monomer)

gene symbol :

TNFRSF9

details of functionality :

Measured by its binding ability in a functional ELISA. When recombinant human 4-1BB Fc Chimera is Immobilized at 10 ng/mL (100 µL/well), the concentration of recombinant human 4-1BB Ligand (Catalog # 2295-4L) that produces 50% optimal binding response is found to be approximately 0.5-2.5 ng/mL.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q07011

applications :

Binding Activity

source :

NS0-derived Recombinant Human 4-1BB/TNFRSF9 Fc Chimera Protein, CF

USD :

377

USD 2023 :

377 USD

alt names :

41BB, 4-1BB, 4-1BB ligand receptor, CD137, CD137 antigen, CD137MGC2172, CDw137, FLJ43501, ILA, ILAhomolog of mouse 4-1BB, induced by lymphocyte activation (ILA), interleukin-activated receptor, homolog of mouse Ly63, receptor protein 4-1BB, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, tumor necrosis factor receptor superfamily member 9, tumor necrosis factor receptor superfamily, member 9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage