Recombinant Human GALNS Protein, CF | R&D Systems 8269-SU-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human GALNS Protein, CF

catalog :

8269-SU-050

quantity :

50 ug

price :

541 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Piechnik M, Amendum P, Sawamoto K, Stapleton M, Khan S, Fnu N, et al. Sex Difference Leads to Differential Gene Expression Patterns and Therapeutic Efficacy in Mucopolysaccharidosis IVA Murine Model Receiving AAV8 Gene Therapy. Int J Mol Sci. 2022;23: pubmed publisher
Sawamoto K, Karumuthil Melethil S, Khan S, Stapleton M, Bruder J, Danos O, et al. Liver-Targeted AAV8 Gene Therapy Ameliorates Skeletal and Cardiovascular Pathology in a Mucopolysaccharidosis IVA Murine Model. Mol Ther Methods Clin Dev. 2020;18:50-61 pubmed publisher
Chuang C, Lin H, Wang T, Huang S, Lin S. Bio-Plex immunoassay measuring the quantity of lysosomal N-acetylgalactosamine-6-sulfatase protein in dried blood spots for the screening of mucopolysaccharidosis IVA in newborn: a pilot study. BMJ Open. 2017;7:e014410 pubmed publisher

product information

master code :

8269-SU

SKU :

8269-SU-050

product name :

Recombinant Human GALNS Protein, CF

unit size :

50 ug

description :

The Recombinant Human GALNS Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human GALNS Protein, CF has been validated for the following applications: Enzyme Activity.

target :

N-Acetylgalactosamine-6-Sulfatase/GALNS

category :

Proteins and Enzymes

buffer :

Supplied as a 0.2 ╡m filtered solution in Tris and NaCl.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

53-59 kDa, reducing conditions

theoretical molecular weight :

56 kDa

gene symbol :

GALNS

details of functionality :

Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS). The specific activity is 0.5 pmol/min/╡g, as measured under the described conditions.

endotoxin note :

<1.0 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P34059

applications :

Enzyme Activity

source long :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived human N-Acetylgalactosamine-6-Sulfatase/GALNS protein Ala27-His522, with an N-terminal 6-His tag

source short :

Sf 21 (baculovirus)

USD :

541 USD

alt names :

chondroitinase, Chondroitinsulfatase, EC 3.1.6, EC 3.1.6.4, FLJ17434, FLJ42844, FLJ98217, GA6S, galactosamine (N-acetyl)-6-sulfate sulfatase, Galactose-6-sulfate sulfatase, GALNAC6S, GalNAc6S sulfatase, GALNS, GAS, MPS4A, N-acetylgalactosamine-6-sulfatase, NAcetylgalactosamine6Sulfatase, N-acetylgalactosamine-6-sulfate sulfatase

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 ░C as supplied. 3 months, -20 to -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage