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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IFN-beta Protein
catalog :
8234-MB-010
quantity :
10 ug
price :
312 USD
more info or order :
citations: 34
Reference
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Rajwani J, Vishnevskiy D, Turk M, Naumenko V, Gafuik C, Kim D, et al. VSV∆M51 drives CD8+ T cell-mediated tumour regression through infection of both cancer and non-cancer cells. Nat Commun. 2024;15:9933 pubmed publisher
Lu J, Hu Z, Jiang H, Wen Z, Li H, Li J, et al. Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality. J Adv Res. 2024;: pubmed publisher
Shuster M, Lyu Z, Augenstreich J, Mathur S, Ganesh A, Ling J, et al. Salmonella Typhimurium infection inhibits macrophage IFNβ signaling in a TLR4-dependent manner. bioRxiv. 2024;: pubmed publisher
Hardaker E, Sanseviero E, Karmokar A, Taylor D, Milo M, Michaloglou C, et al. The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment. Nat Commun. 2024;15:1700 pubmed publisher
Zhang H, Xue K, Li W, Yang X, Gou Y, Su X, et al. Cullin5 drives experimental asthma exacerbations by modulating alveolar macrophage antiviral immunity. Nat Commun. 2024;15:252 pubmed publisher
Byun H, Singh G, Xu W, Das P, Reyes A, Battenhouse A, et al. Apobec-Mediated Retroviral Hypermutation In Vivo is Dependent on Mouse Strain. bioRxiv. 2023;: pubmed publisher
Xia L, Komissarova A, Jacover A, Shovman Y, Arcila Barrera S, Tornovsky Babeay S, et al. Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation. Nat Commun. 2023;14:6295 pubmed publisher
Li Y, Xue M, Deng X, Dong L, Nguyen L, Ren L, et al. TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal. Cell Stem Cell. 2023;30:1072-1090.e10 pubmed publisher
Dhillon P, Mulholland K, Hu H, Park J, Sheng X, Abedini A, et al. Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development. Nat Commun. 2023;14:559 pubmed publisher
Manet C, Mansuroglu Z, Conquet L, Bortolin V, Comptdaer T, Segrt H, et al. Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response. J Neuroinflammation. 2022;19:307 pubmed publisher
Kwart D, He J, Srivatsan S, Lett C, Golubov J, Oswald E, et al. Cancer cell-derived type I interferons instruct tumor monocyte polarization. Cell Rep. 2022;41:111769 pubmed publisher
Zoellner N, Coesfeld N, De Vos F, Denter J, Xu H, Zimmer E, et al. Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling. Front Microbiol. 2022;13:947169 pubmed publisher
Gibson A, Sateriale A, Dumaine J, Engiles J, Pardy R, Gullicksrud J, et al. A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS Pathog. 2022;18:e1010003 pubmed publisher
Dorman L, Nguyen P, Escoubas C, Vainchtein I, Xiao Y, Lidsky P, et al. A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis. bioRxiv. 2022;: pubmed publisher
Fedoriw A, Shi L, O Brien S, Smitheman K, Wang Y, Hou J, et al. Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses. Cancer Immunol Res. 2022;10:420-436 pubmed publisher
Yang L, Chen S, Zhao Q, Pan C, Peng L, Han Y, et al. Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription. Cell Rep. 2022;38:110302 pubmed publisher
Ka N, Lim G, Hwang S, Kim S, Lee M. IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer. Cell Rep. 2021;37:110138 pubmed publisher
Tan J, Garner M, Regeimbal J, Greene C, Márquez J, Ammendolia D, et al. Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes. Nat Commun. 2021;12:4999 pubmed publisher
Sanmarco L, Wheeler M, Gutiérrez Vázquez C, Polonio C, Linnerbauer M, Pinho Ribeiro F, et al. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021;: pubmed publisher
Lv M, Chen M, Zhang R, Zhang W, Wang C, Zhang Y, et al. Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell Res. 2020;30:966-979 pubmed publisher
Guo X, Ma P, Li Y, Yang Y, Wang C, Xu T, et al. RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense. Cell Death Differ. 2020;: pubmed publisher
Giraldo D, Wilcox D, Longnecker R. The Innate Immune Response to Herpes Simplex Virus 1 Infection Is Dampened in the Newborn Brain and Can Be Modulated by Exogenous Interferon Beta To Improve Survival. MBio. 2020;11: pubmed publisher
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product information
master code :
8234-MB
SKU :
8234-MB-010
product name :
Recombinant Mouse IFN-beta Protein
unit size :
10 ug
description :
The Recombinant Mouse IFN-beta Protein from R&D Systems is derived from HEK293. The Recombinant Mouse IFN-beta Protein has been validated for the following applications: Bioactivity.
target :
IFN-beta
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS and Tween« 80 with BSA as a carrier protein.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
30-38 kDa, reducing conditions
theoretical molecular weight :
20 kDa
gene symbol :
Ifnb1
details of functionality :
Measured in an anti-viral assay using L-929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. Vogel, S.N. et al . (1982) Infect. Immunol. 38 :681. The ED50 for this effect is 1.00-6.00 pg/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse IFN-beta Protein Bioactivity
accessionNumbers :
P01575
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived mouse IFN-beta protein Ile22-Asn182
source short :
HEK293
USD :
312 USD
alt names :
Fibroblast interferon, IFB, IFBIFNB, IFF, IFNB, IFNB1, IFNbeta, IFN-beta, interferon beta, interferon, beta 1, fibroblast, MGC96956
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.