product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IFN-beta Protein, CF
catalog :
8234-MB-010/CF
quantity :
10 ug
price :
312 USD
more info or order :
R&D Systems product webpage
citations: 23
Reference
Dhillon P, Mulholland K, Hu H, Park J, Sheng X, Abedini A, et al. Increased levels of endogenous retroviruses trigger fibroinflammation and play a role in kidney disease development. Nat Commun. 2023;14:559 pubmed publisher
Manet C, Mansuroglu Z, Conquet L, Bortolin V, Comptdaer T, Segrt H, et al. Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response. J Neuroinflammation. 2022;19:307 pubmed publisher
Kwart D, He J, Srivatsan S, Lett C, Golubov J, Oswald E, et al. Cancer cell-derived type I interferons instruct tumor monocyte polarization. Cell Rep. 2022;41:111769 pubmed publisher
Zoellner N, Coesfeld N, De Vos F, Denter J, Xu H, Zimmer E, et al. Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling. Front Microbiol. 2022;13:947169 pubmed publisher
Dorman L, Nguyen P, Escoubas C, Vainchtein I, Xiao Y, Lidsky P, et al. A type I interferon response defines a conserved microglial state required for effective neuronal phagocytosis. bioRxiv. 2022;: pubmed publisher
Fedoriw A, Shi L, O Brien S, Smitheman K, Wang Y, Hou J, et al. Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses. Cancer Immunol Res. 2022;10:420-436 pubmed publisher
Yang L, Chen S, Zhao Q, Pan C, Peng L, Han Y, et al. Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription. Cell Rep. 2022;38:110302 pubmed publisher
Ka N, Lim G, Hwang S, Kim S, Lee M. IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer. Cell Rep. 2021;37:110138 pubmed publisher
Tan J, Garner M, Regeimbal J, Greene C, Márquez J, Ammendolia D, et al. Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes. Nat Commun. 2021;12:4999 pubmed publisher
Sanmarco L, Wheeler M, Gutiérrez Vázquez C, Polonio C, Linnerbauer M, Pinho Ribeiro F, et al. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021;: pubmed publisher
Lv M, Chen M, Zhang R, Zhang W, Wang C, Zhang Y, et al. Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell Res. 2020;30:966-979 pubmed publisher
Guo X, Ma P, Li Y, Yang Y, Wang C, Xu T, et al. RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense. Cell Death Differ. 2020;: pubmed publisher
Giraldo D, Wilcox D, Longnecker R. The Innate Immune Response to Herpes Simplex Virus 1 Infection Is Dampened in the Newborn Brain and Can Be Modulated by Exogenous Interferon Beta To Improve Survival. MBio. 2020;11: pubmed publisher
Hosseini S, Michaelsen Preusse K, Grigoryan G, Chhatbar C, Kalinke U, Korte M. Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS. Cell Rep. 2020;31:107666 pubmed publisher
Ziegler C, Allon S, Nyquist S, Mbano I, Miao V, Tzouanas C, et al. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020;181:1016-1035.e19 pubmed publisher
Muthalagu N, Monteverde T, Raffo Iraolagoitia X, Wiesheu R, Whyte D, Hedley A, et al. Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2020;10:872-887 pubmed publisher
Wong S, Huang B, Hu X, Ho Kim E, Kolb J, Padilla R, et al. Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease. Cell Death Differ. 2019;: pubmed publisher
Giebel A, Hu S, Rajaram K, Finethy R, Toh E, Brothwell J, et al. Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture. MBio. 2019;10: pubmed publisher
Singanayagam A, Glanville N, Girkin J, Ching Y, Marcellini A, Porter J, et al. Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations. Nat Commun. 2018;9:2229 pubmed publisher
Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman H, Meriwether D, et al. Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum. J Lipid Res. 2017;58:1636-1647 pubmed publisher
Hunger A, Medrano R, Zanatta D, Del Valle P, Merkel C, Salles T, et al. Reestablishment of p53/Arf and interferon-β pathways mediated by a novel adenoviral vector potentiates antiviral response and immunogenic cell death. Cell Death Discov. 2017;3:17017 pubmed publisher
Xiao Y, Zou Q, Xie X, Liu T, Li H, Jie Z, et al. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med. 2017;214:1493-1507 pubmed publisher
Kilbey A, Terry A, Wotton S, Borland G, Zhang Q, Mackay N, et al. Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis. J Cell Biochem. 2017;118:1432-1441 pubmed publisher
product information
master code :
8234-MB/CF
SKU :
8234-MB-010/CF
product name :
Recombinant Mouse IFN-beta Protein, CF
unit size :
10 ug
description :
The Recombinant Mouse IFN-beta Protein, CF from R&D Systems is derived from HEK293. The Recombinant Mouse IFN-beta Protein, CF has been validated for the following applications: Bioactivity.
target :
IFN-beta
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS and Tween« 80.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
30-38 kDa, reducing conditions
theoretical molecular weight :
20 kDa
gene symbol :
Ifnb1
details of functionality :
Measured in an anti-viral assay using L-929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. Vogel, S.N. et al . (1982) Infect. Immunol. 38 :681. The ED50 for this effect is 1.00-6.00 pg/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Mouse IFN-beta Protein Bioactivity
accessionNumbers :
P01575
applications :
Bioactivity
source long :
Human embryonic kidney cell, HEK293-derived mouse IFN-beta protein Ile22-Asn182
source short :
HEK293
USD :
312 USD
alt names :
Fibroblast interferon, IFB, IFBIFNB, IFF, IFNB, IFNB1, IFNbeta, IFN-beta, interferon beta, interferon, beta 1, fibroblast, MGC96956
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.