Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag) Protein | R&D Systems 8230-CL-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag) Protein

catalog :

8230-CL-050

quantity :

50 ug

price :

423 USD

more info or order :

R&D Systems product webpage

citations: 20

Reference
Di Pietro A, Polmear J, Cooper L, Damelang T, Hussain T, Hailes L, et al. Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection. Nat Immunol. 2022;23:86-98 pubmed publisher
Kealy L, Di Pietro A, Hailes L, Scheer S, Dalit L, Groom J, et al. The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses. Cell Rep. 2020;33:108504 pubmed publisher
Abdi K, Laky K, Padhan K, Petrovas C, Skinner J, Kabat J, et al. Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells. J Immunol. 2018;201:2879-2884 pubmed publisher
Russell M, Muralidharan A, Larocque L, Cao J, Deschambault Y, Varga J, et al. Identification and characterisation of the CD40-ligand of Sigmodon hispidus. PLoS ONE. 2018;13:e0199067 pubmed publisher
Trezise S, Karnowski A, Fedele P, Mithraprabhu S, Liao Y, D Costa K, et al. Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins. Int J Mol Sci. 2018;19: pubmed publisher
Barwick B, Scharer C, Martinez R, Price M, Wein A, Haines R, et al. B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation. Nat Commun. 2018;9:1900 pubmed publisher
Kumar A, Priya A, Ahmed T, Grundström C, Negi N, Grundström T. Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination. J Immunol. 2018;200:4146-4156 pubmed publisher
Scharer C, Barwick B, Guo M, Bally A, Boss J. Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs. Nat Commun. 2018;9:1698 pubmed publisher
Ochiai K, Kondo H, Okamura Y, Shima H, Kurokochi Y, Kimura K, et al. Zinc finger-IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cell. Blood Adv. 2018;2:883-894 pubmed publisher
Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, et al. T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate. Immunity. 2018;48:702-715.e4 pubmed publisher
Miura Y, Morooka M, Sax N, Roychoudhuri R, Itoh Nakadai A, Brydun A, et al. Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors. J Immunol. 2018;200:2882-2893 pubmed publisher
Cosenza S, Toupet K, Maumus M, Luz Crawford P, Blanc Brude O, Jorgensen C, et al. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis. Theranostics. 2018;8:1399-1410 pubmed publisher
Burbage M, Keppler S, Montaner B, Mattila P, Batista F. The Small Rho GTPase TC10 Modulates B Cell Immune Responses. J Immunol. 2017;199:1682-1695 pubmed publisher
Lee B, Lee S, Choo M, Kim J, Lee H, Kim S, et al. Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo. Sci Rep. 2017;7:5119 pubmed publisher
Varthaman A, Moreau H, Maurin M, Benaroch P. TLR3-Induced Maturation of Murine Dendritic Cells Regulates CTL Responses by Modulating PD-L1 Trafficking. PLoS ONE. 2016;11:e0167057 pubmed publisher
Hauser J, Grundström C, Kumar R, Grundström T. Regulated localization of an AID complex with E2A, PAX5 and IRF4 at the Igh locus. Mol Immunol. 2016;80:78-90 pubmed publisher
Ackermann J, Nys J, Schweighoffer E, McCleary S, Smithers N, Tybulewicz V. Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival. J Immunol. 2015;194:4650-6 pubmed publisher
Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, et al. IKK-induced NF-ÎºB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. J Exp Med. 2014;211:2085-101 pubmed publisher
Song Z, Zhu X, Jin R, Wang C, Yan J, Zheng Q, et al. Roles of the kinase TAK1 in CD40-mediated effects on vascular oxidative stress and neointima formation after vascular injury. PLoS ONE. 2014;9:e101671 pubmed publisher
Figgett W, Fairfax K, Vincent F, Le Page M, Katik I, Deliyanti D, et al. The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death. Immunity. 2013;39:573-83 pubmed publisher

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

8230-CL

SKU :

8230-CL-050

product name :

Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag) Protein

Description :

The Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag) Protein from R&D Systems is derived from CHO. The Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag) Protein has been validated for the following applications: Bioactivity.

target :

CD40 Ligand/TNFSF5

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein.

conjugate :

Unconjugated

purity :

>95%, by SDS-PAGE with silver staining.

species :

Mouse

observed molecular weight :

24-29 kDa, reducing conditions

theoretical molecular weight :

22 kDa

gene symbol :

Cd40lg

details of functionality :

Measured in a cell proliferation assay using mouse splenic B cells in the presence of IL-4. Banchereau, J. et al . (1991) Science 251 :70. The ED50 for this effect is 0.0700-0.350 ng/mL in the presence of a cross-linking antibody, Mouse Anti-Hemagglutinin/HA Peptide Monoclonal Antibody (Catalog # MAB060 ).

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P27548

applications :

Bioactivity

source :

CHO-derived Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag) Protein

extended description :

Analyzed by SEC-MALS

USD :

423 USD

product details :

Analyzed by SEC-MALS

alt names :

CD154, CD154 antigen, CD40 antigen ligand, CD40 ligand, CD40L, CD40-L, CD40LG, CD40LIGM, gp39, hCD40L, HIGM1, T-B cell-activating molecule, T-BAM, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TNFSF5IMD3, TRAP, TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome), tumor necrosis factor (ligand) superfamily member 5, Tumor necrosis factor ligand superfamily member 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage