product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human S100A8/S100A9 Heterodimer Protein, CF
catalog :
8226-S8-050
quantity :
50 ug
price :
468 USD
more info or order :
R&D Systems product webpage
citations: 10
Reference
Chen Q, Ishii K, Mori H, Nishijima A, Arai S, Miyazaki T, et al. Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M. Nat Commun. 2024;15:9387 pubmed publisher
Basova L, Lindsey A, McGovern A, Rosander A, Delorme Walker V, ElShamy W, et al. MRP8/14 Is a Molecular Signature Triggered by Dopamine in HIV Latent Myeloid Targets That Increases HIV Transcription and Distinguishes HIV+ Methamphetamine Users with Detectable CSF Viral Load and Brain Pathology. Viruses. 2023;15: pubmed publisher
de Almeida L, Young D, Chow L, Nicholas J, Lee A, Poon M, et al. Proteomics and Metabolomics Profiling of Platelets and Plasma Mediators of Thrombo-Inflammation in Gestational Hypertension and Preeclampsia. Cells. 2022;11: pubmed publisher
Li Z, McGinn O, Wu Y, Bahreini A, Priedigkeit N, Ding K, et al. ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation. Nat Commun. 2022;13:2011 pubmed publisher
Maehara N, Taniguchi K, Okuno A, Ando H, Hirota A, Li Z, et al. AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke. Cell Rep. 2021;36:109693 pubmed publisher
Bisson D, Sheng K, Kocabas S, Krock E, Teles A, Saran N, et al. Toll-like receptor involvement in adolescent scoliotic facet joint degeneration. J Cell Mol Med. 2020;24:11355-11365 pubmed publisher
Rolfes V, Ribeiro L, Hawwari I, Böttcher L, Rosero N, Maasewerd S, et al. Platelets Fuel the Inflammasome Activation of Innate Immune Cells. Cell Rep. 2020;31:107615 pubmed publisher
Dubois C, Marcé D, Faivre V, Lukaszewicz A, Junot C, Fenaille F, et al. High plasma level of S100A8/S100A9 and S100A12 at admission indicates a higher risk of death in septic shock patients. Sci Rep. 2019;9:15660 pubmed publisher
Sun J, Pan X, Christiansen L, Yuan X, Skovgaard K, Chatterton D, et al. Necrotizing enterocolitis is associated with acute brain responses in preterm pigs. J Neuroinflammation. 2018;15:180 pubmed publisher
Basu A, Munir S, Mulaw M, Singh K, Crisan D, Sindrilaru A, et al. A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells associated with Enhanced Wound Healing. Sci Rep. 2018;8:6205 pubmed publisher
product information
master code :
8226-S8
SKU :
8226-S8-050
product name :
Recombinant Human S100A8/S100A9 Heterodimer Protein, CF
unit size :
50 ug
description :
The Recombinant Human S100A8/S100A9 Heterodimer Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human S100A8/S100A9 Heterodimer Protein, CF has been validated for the following applications: Binding Activity.
target :
S100A8/S100A9 Heterodimer
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS and DTT.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Human
observed molecular weight :
9 kDa (S100A8) 13 kDa (S100A9), reducing conditions
theoretical molecular weight :
11 kDa (S100A8) 13 kDa (S100A9)
gene symbol :
S100A8
details of functionality :
Measured by its ability to induce IL-6 secretion by A375 human melanoma cells. Hibino, T. et al . (2013) Cancer Res. 73 :172. The ED50 for this effect is 1.5-6 ╡g/mL.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
top caption :
Recombinant Human S100A8/S100A9 Heterodimer Protein Bioactivity
accessionNumbers :
P05109 (S100A8) P06702 (S100A9)
applications :
Binding Activity
source long :
E. coli -derived human S100A8/S100A9 Heterodimer protein Met1-Glu93 (S100A8) & Thr2-Pro114 (S100A9)
source short :
E. coli
USD :
468 USD
alt names :
60B8AG, CAGA, calgranulin A, Calprotectin, Calprotectin L1L subunit, CFAG, CGLA, CP-10, Cystic fibrosis antigen, L1AG, Leukocyte L1 complex light chain, MA387, MIF, Migration inhibitory factor-related protein 8, MRP8, NIF, p8, protein S100-A8, S100-A8, Urinary stone protein band A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.