product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Viral B18R Protein, CF
catalog :
8185-BR-025
quantity :
25 ug
price :
308 USD
more info or order :
citations: 4
Reference
Chen Q, Coto Llerena M, Suslov A, Teixeira R, Fofana I, Nuciforo S, et al. Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses. Nat Commun. 2021;12:4882 pubmed publisher
Nazitto R, Amon L, Mast F, Aitchison J, Aderem A, Johnson J, et al. ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation. J Immunol. 2021;: pubmed publisher
Imamichi T, Goswami S, Hu X, Laverdure S, Yang J, Qiu J, et al. MicroRNA Profiles in Monocyte-Derived Macrophages Generated by Interleukin-27 and Human Serum: Identification of a Novel HIV-Inhibiting and Autophagy-Inducing MicroRNA. Int J Mol Sci. 2021;22: pubmed publisher
Swaim C, Canadeo L, Monte K, Khanna S, Lenschow D, Huibregtse J. Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins. Cell Rep. 2020;31:107772 pubmed publisher
image
image 1 :
R&D Systems 8185-BR-025 image 1
B18R Inhibits Type-I IFN-mediated anti-viral activity.
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
8185-BR
SKU :
8185-BR-025
product name :
Recombinant Viral B18R Protein, CF
Description :
The Recombinant Viral B18R Protein, CF from R&D Systems is derived from HEK293. The Recombinant Viral B18R Protein, CF has been validated for the following applications: Bioactivity.
target :
B18R
category :
Proteins and Enzymes
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
species :
Viral
observed molecular weight :
80-95 kDa, reducing conditions
theoretical molecular weight :
65 kDa (monomer)
gene symbol :
B19R
details of functionality :
Measured by its ability to inhibit Type-I IFN-mediated anti-viral activity. Symons, J.A. et al . (1995) Cell 81 :551. The ED50 for this effect, as measured by inhibition of Recombinant Human IFN-alpha 2 (Catalog # 11105-1 ) , is 0.3-1.8 ng/mL.
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P25213
applications :
Bioactivity
source :
HEK293-derived Recombinant Viral B18R Protein
extended description :
Type I IFN Inhibitor
USD :
308 USD
product details :
Type I IFN Inhibitor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.