Recombinant Viral B18R Protein, CF | R&D Systems 8185-BR-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Viral B18R Protein, CF

catalog :

8185-BR-025

quantity :

25 ug

price :

312 USD

citations: 6

Reference
Garc xed a M, Carrasco Garc xed a A, Weigel W, Christ W, Lira Júnior R, Wirth L, et al. Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons. PLoS Pathog. 2024;20:e1012390 pubmed publisher
Lodge R, Xu Z, Eklund M, St xfc rzel C, Kirchhoff F, Tremblay M, et al. MicroRNA-25/93 induction by Vpu as a mechanism for counteracting MARCH1-restriction on HIV-1 infectivity in macrophages. MBio. 2023;14:e0195023 pubmed publisher
Chen Q, Coto Llerena M, Suslov A, Teixeira R, Fofana I, Nuciforo S, et al. Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses. Nat Commun. 2021;12:4882 pubmed publisher
Nazitto R, Amon L, Mast F, Aitchison J, Aderem A, Johnson J, et al. ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation. J Immunol. 2021;: pubmed publisher
Imamichi T, Goswami S, Hu X, Laverdure S, Yang J, Qiu J, et al. MicroRNA Profiles in Monocyte-Derived Macrophages Generated by Interleukin-27 and Human Serum: Identification of a Novel HIV-Inhibiting and Autophagy-Inducing MicroRNA. Int J Mol Sci. 2021;22: pubmed publisher
Swaim C, Canadeo L, Monte K, Khanna S, Lenschow D, Huibregtse J. Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins. Cell Rep. 2020;31:107772 pubmed publisher

product information

master code :

8185-BR

SKU :

8185-BR-025

product name :

Recombinant Viral B18R Protein, CF

unit size :

25 ug

description :

The Recombinant Viral B18R Protein, CF from R&D Systems is derived from HEK293. The Recombinant Viral B18R Protein, CF has been validated for the following applications: Bioactivity.

target :

B18R

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Viral

observed molecular weight :

80-95 kDa, reducing conditions

theoretical molecular weight :

65 kDa (monomer)

gene symbol :

B19R

details of functionality :

Measured by its ability to inhibit Type-I IFN-mediated anti-viral activity. Symons, J.A. et al . (1995) Cell 81 :551. The ED50 for this effect, as measured by inhibition of Recombinant Human IFN-alpha 2 (Catalog # 11105-1 ) , is 0.3-1.8 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

top caption :

B18R Inhibits Type-I IFN-mediated anti-viral activity.

accessionNumbers :

P25213

applications :

Bioactivity

source long :

Human embryonic kidney cell, HEK293-derived viral B18R protein MD Human IgG1 (Pro100-Lys300) IEGR Viral B18R (His20-Glu351) Accession # P25213 N-terminus C-terminus

source short :

HEK293

extended description :

Type I IFN Inhibitor

USD :

312 USD

product details :

Type I IFN Inhibitor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied.