Recombinant Viral B18R Protein, CF | R&D Systems 8185-BR-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Viral B18R Protein, CF

catalog :

8185-BR-025

quantity :

25 ug

price :

308 USD

more info or order :

R&D Systems product webpage

citations: 4

Reference
Chen Q, Coto Llerena M, Suslov A, Teixeira R, Fofana I, Nuciforo S, et al. Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses. Nat Commun. 2021;12:4882 pubmed publisher
Nazitto R, Amon L, Mast F, Aitchison J, Aderem A, Johnson J, et al. ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation. J Immunol. 2021;: pubmed publisher
Imamichi T, Goswami S, Hu X, Laverdure S, Yang J, Qiu J, et al. MicroRNA Profiles in Monocyte-Derived Macrophages Generated by Interleukin-27 and Human Serum: Identification of a Novel HIV-Inhibiting and Autophagy-Inducing MicroRNA. Int J Mol Sci. 2021;22: pubmed publisher
Swaim C, Canadeo L, Monte K, Khanna S, Lenschow D, Huibregtse J. Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins. Cell Rep. 2020;31:107772 pubmed publisher

image

image 1 :

B18R Inhibits Type-I IFN-mediated anti-viral activity.

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

8185-BR

SKU :

8185-BR-025

product name :

Recombinant Viral B18R Protein, CF

Description :

The Recombinant Viral B18R Protein, CF from R&D Systems is derived from HEK293. The Recombinant Viral B18R Protein, CF has been validated for the following applications: Bioactivity.

target :

B18R

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

species :

Viral

observed molecular weight :

80-95 kDa, reducing conditions

theoretical molecular weight :

65 kDa (monomer)

gene symbol :

B19R

details of functionality :

Measured by its ability to inhibit Type-I IFN-mediated anti-viral activity. Symons, J.A. et al . (1995) Cell 81 :551. The ED50 for this effect, as measured by inhibition of Recombinant Human IFN-alpha 2 (Catalog # 11105-1 ) , is 0.3-1.8 ng/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

P25213

applications :

Bioactivity

source :

HEK293-derived Recombinant Viral B18R Protein

extended description :

Type I IFN Inhibitor

USD :

308 USD

product details :

Type I IFN Inhibitor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied.

more info or order :

R&D Systems product webpage