Recombinant Human cIAP-1 (HIAP-2) Protein, CF | R&D Systems 818-IA-050 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human cIAP-1 (HIAP-2) Protein, CF

catalog :

818-IA-050

quantity :

50 ug

price :

447 USD

more info or order :

R&D Systems product webpage

citations: 6

Reference
Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi P, Droin N, et al. DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues. Cell Death Dis. 2017;8:e2816 pubmed publisher
Lee E, Seong D, Seo J, Jeong M, Lee H, Song J. USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics. Cell Death Differ. 2015;22:1463-76 pubmed publisher
Guicciardi M, Werneburg N, Bronk S, Franke A, Yagita H, Thomas G, et al. Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS ONE. 2014;9:e92124 pubmed publisher
Oberoi Khanuja T, Karreman C, Larisch S, Rapp U, Rajalingam K. Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration. J Biol Chem. 2012;287:28445-55 pubmed publisher
Sekine K, Takubo K, Kikuchi R, Nishimoto M, Kitagawa M, Abe F, et al. Small molecules destabilize cIAP1 by activating auto-ubiquitylation. J Biol Chem. 2008;283:8961-8 pubmed publisher
Balasubramanian S, Mani S, Shiraishi H, Johnston R, Yamane K, Willey C, et al. Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases. J Mol Cell Cardiol. 2006;41:669-79 pubmed

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

818-IA

SKU :

818-IA-050

product name :

Recombinant Human cIAP-1 (HIAP-2) Protein, CF

Description :

The Recombinant Human cIAP-1 (HIAP-2) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human cIAP-1 (HIAP-2) Protein, CF has been validated for the following applications: Inhibition Activity.

target :

cIAP-1/HIAP-2

category :

Proteins and Enzymes

unit size :

50 ug

buffer :

Supplied as a 0.2 µm filtered solution in HEPES, NaCl, DTT and Glycerol.

conjugate :

Unconjugated

purity :

>85%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

68 kDa, reducing conditions

theoretical molecular weight :

72 kDa

gene symbol :

BIRC2

details of functionality :

Measured by its ability to inhibit DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP. The IC50 for this effect is 25-1000 nM. Optimal dilutions should be determined by each laboratory for each application.

accessionNumbers :

Q13490

applications :

Inhibition Activity

source :

E. coli-derived Recombinant Human cIAP-1 (HIAP-2) Protein

USD :

447 USD

alt names :

API1Hiap-2, apoptosis inhibitor 1, baculoviral IAP repeat containing 2, baculoviral IAP repeat-containing 2, baculoviral IAP repeat-containing protein 2, BIRC2, cIAP1, C-IAP1, hIAP2, HIAP-2, IAP homolog B, IAP2, IAP-2, Inhibitor of apoptosis protein 2, MIHB, MIHBHIAP2, NFR2-TRAF signalling complex protein, RING finger protein 48, RNF48hiap-2, TNFR2-TRAF-signaling complex protein 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage