product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human cIAP-2 (HIAP-1) Protein, CF
catalog :
817-P2-050
quantity :
50 ug
price :
541 USD
more info or order :
R&D Systems product webpage
citations: 2
Reference
Lee E, Seong D, Seo J, Jeong M, Lee H, Song J. USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics. Cell Death Differ. 2015;22:1463-76 pubmed publisher
Guicciardi M, Werneburg N, Bronk S, Franke A, Yagita H, Thomas G, et al. Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS ONE. 2014;9:e92124 pubmed publisher
product information
master code :
817-P2
SKU :
817-P2-050
product name :
Recombinant Human cIAP-2 (HIAP-1) Protein, CF
unit size :
50 ug
description :
The Recombinant Human cIAP-2 (HIAP-1) Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human cIAP-2 (HIAP-1) Protein, CF has been validated for the following applications: Inhibition Activity.
target :
cIAP-2/HIAP-1
category :
Proteins and Enzymes
buffer :
Supplied as a 0.2 ╡m filtered solution in HEPES, NaCl, DTT and Glycerol.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
73 kDa, reducing conditions
theoretical molecular weight :
71 kDa
gene symbol :
BIRC3
details of functionality :
Measured by its ability to inhibit DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP. The IC50 for this effect is 25-1000 nM. Optimal dilutions should be determined by each laboratory for each application.
accessionNumbers :
Q13489
applications :
Inhibition Activity
source long :
E. coli -derived human cIAP-2/HIAP-1 protein ATVID 10-His tag SIEGRA Human cIAP-2 (Asn2-Ser604) Accession # Q13489 N-terminus C-terminus
source short :
E. coli
USD :
541 USD
alt names :
AIP1, API2, BIRC3, BIRC3 baculoviral IAP repeat containing 3, c-IAP2, CIAP2, HAIP1, HIAP1, HIAP-1, MALT2, MIHC, RNF49
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.