Recombinant Human/Mouse BMPR-II Fc Chimera Protein, CF | R&D Systems 811-BR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human/Mouse BMPR-II Fc Chimera Protein, CF

catalog :

811-BR-100

quantity :

100 ug

price :

483 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Guo J, Liu B, Thorikay M, Yu M, Li X, Tong Z, et al. Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun. 2022;13:2395 pubmed publisher
Cate R, di Clemente N, Racine C, Groome N, Pepinsky R, Whitty A. The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor. J Biol Chem. 2022;298:101429 pubmed publisher
Mang T, Kleinschmidt Doerr K, Ploeger F, Schoenemann A, Lindemann S, Gigout A. BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation. J Cell Sci. 2020;133: pubmed publisher
Huang B, Yuan Y, Li T, Ding S, Zhang W, Gu Y, et al. Facilitated receptor-recognition and enhanced bioactivity of bone morphogenetic protein-2 on magnesium-substituted hydroxyapatite surface. Sci Rep. 2016;6:24323 pubmed publisher
Kienast Y, Jucknischke U, Scheiblich S, Thier M, de Wouters M, Haas A, et al. Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains. J Biol Chem. 2016;291:3395-410 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Serpe M, Umulis D, Ralston A, Chen J, Olson D, Avanesov A, et al. The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. Dev Cell. 2008;14:940-53 pubmed publisher
Reversade B, De Robertis E. Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 2005;123:1147-60 pubmed

product information

brand :

R&D Systems

master code :

811-BR

SKU :

811-BR-100

product name :

Recombinant Human/Mouse BMPR-II Fc Chimera Protein, CF

description :

The Recombinant Human/Mouse BMPR-II Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human/Mouse BMPR-II Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

target :

BMPR-II

category :

Proteins and Enzymes

sizes available :

100 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human, Mouse

observed molecular weight :

65-75 kDa, reducing conditions

theoretical molecular weight :

41.5 kDa (monomer)

gene symbol :

BMPR2

details of functionality :

Measured by its binding ability in a functional ELISA. When Recombinant Mouse GDF-9 (Catalog # 739-G9) is immobilized at 2 µg/mL (100 µL/well), the concentration of Recombinant Human/Mouse BMPR-II Fc Chimera that produces 50% of the optimal binding response is found to be approximately 0.1 - 0.5 µg/mL.

endotoxin note :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

Q13873

applications :

Bioactivity

source :

NS0-derived Recombinant Human/Mouse BMPR-II Fc Chimera Protein, CF

USD :

475

USD 2023 :

483 USD

alt names :

BMP type II receptor, BMP type-2 receptor, BMPR2, BMPR-2, BMPR3, BMPRII, BMPR-IIprimary pulmonary hypertension 1, Bone morphogenetic protein receptor type II, bone morphogenetic protein receptor type-2, bone morphogenetic protein receptor, type II (serine/threonine kinase), BRK-3, EC 2.7.11, EC 2.7.11.30, FLJ41585, FLJ76945, PPH1BMR2, T-ALK, type II activin receptor-like kinase, type II receptor for bone morphogenetic protein-4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage