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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse Complement Component C3a Protein, CF
catalog :
8085-C3-025
quantity :
25 ug
price :
502 USD
more info or order :
R&D Systems product webpage
citations: 13
Reference
Kuhn M, VandenBerg H, Reynolds A, Carson M, Warner A, LaRue A, et al. C3a-C3aR signaling is a novel modulator of skeletal homeostasis. Bone Rep. 2023;18:101662 pubmed publisher
Cohen A, Jeng E, Voorhies M, Symington J, Ali N, Rodríguez R, et al. Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages. PLoS Pathog. 2022;18:e1010237 pubmed publisher
Ito S, Hashimoto H, Yamakawa H, Kusumoto D, Akiba Y, Nakamura T, et al. The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure. Nat Commun. 2022;13:5409 pubmed publisher
Llori xe1 n Salvador M, Byrne E, Szczepan M, Little K, Chen M, Xu H. Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells. J Neuroinflammation. 2022;19:182 pubmed publisher
Gong B, Guo D, Zheng C, Ma Z, Zhang J, Qu Y, et al. Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α. J Neuroinflammation. 2022;19:159 pubmed publisher
Zheng Z, Li Y, Jia S, Zhu M, Cao L, Tao M, et al. Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3. Nat Commun. 2021;12:6202 pubmed publisher
Consonni F, Bleve A, Totaro M, Storto M, Kunderfranco P, Termanini A, et al. Heme catabolism by tumor-associated macrophages controls metastasis formation. Nat Immunol. 2021;22:595-606 pubmed publisher
Hsu B, Roy J, Mouhanna J, Rayes R, Ramsay L, Tabariès S, et al. C3a elicits unique migratory responses in immature low-density neutrophils. Oncogene. 2020;39:2612-2623 pubmed publisher
Xiong C, Liu J, Lin D, Zhang J, Terrando N, Wu A. Complement activation contributes to perioperative neurocognitive disorders in mice. J Neuroinflammation. 2018;15:254 pubmed publisher
Braun C, Kalbitz M, Halbgebauer R, Eisele P, Messerer D, Weckbach S, et al. Early structural changes of the heart after experimental polytrauma and hemorrhagic shock. PLoS ONE. 2017;12:e0187327 pubmed publisher
Bax H, Bowen H, Beavil R, Chung R, Ward M, Davies A, et al. IgE Trimers Drive SPE-7 Cytokinergic Activity. Sci Rep. 2017;7:8164 pubmed publisher
Zhao X, Larkin T, Lauver M, Ahmad S, Ducruet A. Tissue plasminogen activator mediates deleterious complement cascade activation in stroke. PLoS ONE. 2017;12:e0180822 pubmed publisher
Lebel M, Langlois M, Daudelin J, Tarrab E, Savard P, Leclerc D, et al. Complement Component 3 Regulates IFN-? Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus-like Nanoparticle. J Immunol. 2017;198:292-299 pubmed
product information
brand :
R&D Systems, a Bio-Techne brand
catalog number base :
8085-C3
SKU :
8085-C3-025
product name :
Recombinant Mouse Complement Component C3a Protein, CF
description :
The Recombinant Mouse Complement Component C3a Protein, CF from R&D Systems is derived from E. coli. The Recombinant Mouse Complement Component C3a Protein, CF has been validated for the following applications: Bioactivity.
target :
Complement Component C3a
unit size :
25 ug
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
observed molecular weight :
9 kDa, reducing conditions
theoretical molecular weight :
9.2 kDa
gene symbol :
C3
details of functionality :
Measured by its ability to enhance IL-6 secretion by human peripheral blood mononuclear cells (PBMC). Fischer, W.H. et al . (1999) J. Immunol. 162 :453. The ED50 for this effect is typically 0.8-4 µg/mL
endotoxin note :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P01027
applications :
Bioactivity
product keywords :
8085-C3, rmC3a, mC3a, carrier-free, carrier free, 8O85-C3, 8085C3, ComplementComponentC3a
source :
E. coli-derived Recombinant Mouse Complement Component C3a Protein, CF
USD :
487
USD 2025 :
502 USD
alt names :
AHUS5;ARMD9;ASP;C3a;C3b;Complement C3;CPAMD1;HEL-S-62p, Anaphylatoxin, C3
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.