Recombinant Human Activin RIB/ALK-4 Fc Chimera Protein, CF | R&D Systems 808-AR-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Activin RIB/ALK-4 Fc Chimera Protein, CF

catalog :

808-AR-100

quantity :

100 ug

price :

456 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Aykul S, Huang L, Wang L, Das N, Reisman S, Ray Y, et al. Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1. J Clin Invest. 2022;132: pubmed publisher
Kumar R, Grinberg A, Li H, Kuo T, Sako D, Krishnan L, et al. Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily. Sci Rep. 2021;11:18341 pubmed publisher
Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher

product information

master code :

808-AR

SKU :

808-AR-100

product name :

Recombinant Human Activin RIB/ALK-4 Fc Chimera Protein, CF

unit size :

100 ug

description :

The Recombinant Human Activin RIB/ALK-4 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human Activin RIB/ALK-4 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.

target :

Activin RIB/ALK-4

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

45-50 kDa, reducing conditions

theoretical molecular weight :

37.5 kDa (monomer)

gene symbol :

ACVR1B

details of functionality :

Measured by its binding ability in a functional ELISA. Immobilized rhActivin RIB/Fc Chimera at 2 ╡g/mL (100 ╡L/well) can bind rhCripto with a linear range of 0.8-100 ng/mL.

endotoxin note :

<0.10 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

AAA60556

applications :

Binding Activity

source long :

Mouse myeloma cell line, NS0-derived human Activin RIB/ALK-4 protein Human Activin RIB (Leu32 - Glu126) Accession # AAA60556 IEGRMD Human IgG1 (Pro100 - Lys330) 6-His tag N-terminus C-terminus

source short :

NS0

USD :

456 USD

alt names :

activin A receptor, type IB, Activin receptor type IB, Activin receptor-like kinase 4, ActivinRIB, ActRIB, ACVR1B, ACVRLK4ACTR-IB, ALK4, ALK-4, ALK4activin A receptor, type II-like kinase 4, EC 2.7.11, EC 2.7.11.30, Serine/threonine-protein kinase receptor R2, SKR2activin receptor type-1B

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage