Recombinant Human IGFBP-4 Protein, CF | R&D Systems 804-GB product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human IGFBP-4 Protein, CF

catalog :

804-GB

quantity :

25 ug

price :

329 USD

citations: 7

Reference
Wirthgen E, Goumon S, Kunze M, Walz C, Spitschak M, Tuchscherer A, et al. Effects of Transport Duration and Environmental Conditions in Winter or Summer on the Concentrations of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Plasma of Market-Weight Pigs. Front Endocrinol (Lausanne). 2018;9:36 pubmed publisher
Crosley E, Dunk C, Beristain A, Christians J. IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells. Reprod Biol Endocrinol. 2014;12:123 pubmed publisher
Eckstein N, Servan K, Hildebrandt B, Pölitz A, von Jonquieres G, Wolf Kümmeth S, et al. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res. 2009;69:2996-3003 pubmed publisher
Wang T, Chang C, Wu H, Chiu Y, Chen C, Wang H. Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. Fertil Steril. 2006;86:1392-401 pubmed
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed
Wunder D, Mueller M, Birkhäuser M, Bersinger N. Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis. J Assist Reprod Genet. 2005;22:257-64 pubmed
Nakamura M, Miyamoto S, Maeda H, Ishii G, Hasebe T, Chiba T, et al. Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability. Biochem Biophys Res Commun. 2005;333:1011-6 pubmed

product information

brand :

R&D Systems

master code :

804-GB

SKU :

804-GB-025

product name :

Recombinant Human IGFBP-4 Protein, CF

description :

The Recombinant Human IGFBP-4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IGFBP-4 Protein, CF has been validated for the following applications: Bioactivity.

target :

IGFBP-4

category :

Proteins and Enzymes

unit size :

25 ug

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS.

conjugate :

Unconjugated

purity :

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Human

observed molecular weight :

32 kDa, reducing conditions

theoretical molecular weight :

26 kDa

gene symbol :

IGFBP4

details of functionality :

Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 0.03-0.09 µg/mL in the presence of 14 ng/mL recombinant human IGF-II.

endotoxin note :

<0.01 EU per 1 µg of the protein by the LAL method.

catalog number base :

804-GB

accessionNumbers :

AAA62670

applications :

Bioactivity

source :

Mouse myeloma cell line, NS0-derived human IGFBP-4 protein Asp22-Glu258, with an N-terminal Met

2020 USD :

329

2021 USD :

329 USD

alt names :

BP-4, HT29-IGFBP, IBP4insulin-like growth factor-binding protein 4, IGF-binding protein 4, IGFBP4, IGFBP-4IBP-4, insulin-like growth factor binding protein 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.