product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Human IGFBP-4 Protein, CF
catalog :
804-GB-025
quantity :
25 ug
price :
377 USD
more info or order :
citations: 8
Reference
Mohrin M, Liu J, Zavala Solorio J, Bhargava S, Maxwell Trumble J, Brito A, et al. Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells. Aging Cell. 2021;20:e13313 pubmed publisher
Wirthgen E, Goumon S, Kunze M, Walz C, Spitschak M, Tuchscherer A, et al. Effects of Transport Duration and Environmental Conditions in Winter or Summer on the Concentrations of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Plasma of Market-Weight Pigs. Front Endocrinol (Lausanne). 2018;9:36 pubmed publisher
Crosley E, Dunk C, Beristain A, Christians J. IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells. Reprod Biol Endocrinol. 2014;12:123 pubmed publisher
Eckstein N, Servan K, Hildebrandt B, Pölitz A, von Jonquieres G, Wolf Kümmeth S, et al. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res. 2009;69:2996-3003 pubmed publisher
Wang T, Chang C, Wu H, Chiu Y, Chen C, Wang H. Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. Fertil Steril. 2006;86:1392-401 pubmed
Cortesio C, Jiang W. Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5. Arch Biochem Biophys. 2006;449:164-70 pubmed
Wunder D, Mueller M, Birkhäuser M, Bersinger N. Steroids and protein markers in the follicular fluid as indicators of oocyte quality in patients with and without endometriosis. J Assist Reprod Genet. 2005;22:257-64 pubmed
Nakamura M, Miyamoto S, Maeda H, Ishii G, Hasebe T, Chiba T, et al. Matrix metalloproteinase-7 degrades all insulin-like growth factor binding proteins and facilitates insulin-like growth factor bioavailability. Biochem Biophys Res Commun. 2005;333:1011-6 pubmed
product information
brand :
R&D Systems
master code :
804-GB
SKU :
804-GB-025
product name :
Recombinant Human IGFBP-4 Protein, CF
description :
The Recombinant Human IGFBP-4 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human IGFBP-4 Protein, CF has been validated for the following applications: Bioactivity.
target :
IGFBP-4
category :
Proteins and Enzymes
sizes available :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS.
conjugate :
Unconjugated
purity :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Human
observed molecular weight :
32 kDa, reducing conditions
theoretical molecular weight :
26 kDa
gene symbol :
IGFBP4
details of functionality :
Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 0.03-0.09 µg/mL in the presence of 14 ng/mL recombinant human IGF-II.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAA62670
applications :
Bioactivity
source :
NS0-derived Recombinant Human IGFBP-4 Protein, CF
USD :
377
USD 2023 :
377 USD
alt names :
BP-4, HT29-IGFBP, IBP4insulin-like growth factor-binding protein 4, IGF-binding protein 4, IGFBP4, IGFBP-4IBP-4, insulin-like growth factor binding protein 4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.