Recombinant Human CXCL13/BLC/BCA-1 Protein | R&D Systems 801-CX-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human CXCL13/BLC/BCA-1 Protein

catalog :

801-CX-025

quantity :

25 ug

price :

407 USD

more info or order :

R&D Systems product webpage

citations: 20

Reference
Chao C, Lee W, Wang S, Chen P, Yamamoto A, Chang T, et al. CXC chemokine ligand-13 promotes metastasis via CXCR5-dependent signaling pathway in non-small cell lung cancer. J Cell Mol Med. 2021;25:9128-9140 pubmed publisher
Biasci D, Smoragiewicz M, Connell C, Wang Z, Gao Y, Thaventhiran J, et al. CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response. Proc Natl Acad Sci U S A. 2020;117:28960-28970 pubmed publisher
Ardain A, Domingo Gonzalez R, Das S, Kazer S, Howard N, Singh A, et al. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019;: pubmed publisher
Middleton L, Shen Z, Varma S, Pollack A, Gong X, Zhu S, et al. Genomic analysis of benign prostatic hyperplasia implicates cellular re-landscaping in disease pathogenesis. JCI Insight. 2019;5: pubmed publisher
Reiff S, Mantel R, Smith L, Greene J, Muhowski E, Fabian C, et al. The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation. Cancer Discov. 2018;8:1300-1315 pubmed publisher
Armas González E, Domínguez Luis M, Díaz Martín A, Arce Franco M, Castro Hernandez J, Danelon G, et al. Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis. Arthritis Res Ther. 2018;20:114 pubmed publisher
Chen J, Liu X, Munshi M, Xu L, Tsakmaklis N, Demos M, et al. BTKCys481Ser drives ibrutinib resistance via ERK1/2, and protects BTKWild-Type MYD88 mutated cells by a paracrine mechanism. Blood. 2018;: pubmed publisher
Blackburn M, Zhong Min M, Caccuri F, McKinnon K, Schifanella L, Guan Y, et al. Regulatory and Helper Follicular T Cells and Antibody Avidity to Simian Immunodeficiency Virus Glycoprotein 120. J Immunol. 2015;195:3227-36 pubmed publisher
Boswell K, Paris R, Boritz E, Ambrozak D, Yamamoto T, Darko S, et al. Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection. PLoS Pathog. 2014;10:e1003853 pubmed publisher
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed publisher
Ponader S, Chen S, Buggy J, Balakrishnan K, Gandhi V, Wierda W, et al. The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood. 2012;119:1182-9 pubmed publisher
Weiss N, Deboux C, Chaverot N, Miller F, Baron van Evercooren A, Couraud P, et al. IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells. J Neuroimmunol. 2010;223:131-4 pubmed publisher
Berrih Aknin S, Ruhlmann N, Bismuth J, Cizeron Clairac G, Zelman E, Shachar I, et al. CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. Ann Neurol. 2009;66:521-31 pubmed publisher
Ehlin Henriksson B, Liang W, Cagigi A, Mowafi F, Klein G, Nilsson A. Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection. Immunology. 2009;127:549-57 pubmed publisher
Sansonno D, Tucci F, Troiani L, Lauletta G, Montrone M, Conteduca V, et al. Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis. Blood. 2008;112:1620-7 pubmed publisher
Lim H, Kim C. Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue. J Immunol. 2007;179:7448-56 pubmed
Bürkle A, Niedermeier M, Schmitt Gräff A, Wierda W, Keating M, Burger J. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. Blood. 2007;110:3316-25 pubmed
Lisignoli G, Cristino S, Piacentini A, Cavallo C, Caplan A, Facchini A. Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. J Cell Physiol. 2006;207:364-73 pubmed
Perrier P, Martinez F, Locati M, Bianchi G, Nebuloni M, Vago G, et al. Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13. J Immunol. 2004;172:7031-42 pubmed
Huber T, Reinhardt H, Exner M, Burger J, Kerjaschki D, Saleem M, et al. Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol. 2002;168:6244-52 pubmed

product information

brand :

R&D Systems

master code :

801-CX

SKU :

801-CX-025

product name :

Recombinant Human CXCL13/BLC/BCA-1 Protein

unit size :

25 ug

seo description :

The Recombinant Human CXCL13/BLC/BCA-1 Protein from R&D Systems is derived from E. coli. The Recombinant Human CXCL13/BLC/BCA-1 Protein has been validated for the following applications: Bioactivity.

target :

CXCL13/BLC/BCA-1

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA with BSA as a carrier protein.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.

species :

Human

observed molecular weight :

9 kDa, reducing conditions

theoretical molecular weight :

8.7 kDa

gene symbol :

CXCL13

details of functionality :

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR5. The ED50 for this effect is 0.005-0.02á╡g/mL.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

Q53X90

applications :

Bioactivity

source :

E. coli-derived Recombinant Human CXCL13/BLC/BCA-1 Protein

USD :

407 USD

alt names :

ANGIE, ANGIE2, B cell-attracting chemokine 1, B lymphocyte chemoattractant, BCA1, BCA-1, BCA1B-cell chemoattractant, BCA-1CXC chemokine BLC, B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1), BLC, BLCSmall-inducible cytokine B13, BLR1L, B-lymphocyte chemoattractant, chemokine (C-X-C motif) ligand 13, chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant), C-X-C motif chemokine 13, SCYB13, SCYB13B-cell-attracting chemokine 1, small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage