Recombinant Mouse IGFBP-2 Protein, CF | R&D Systems 797-B2-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Mouse IGFBP-2 Protein, CF

catalog :

797-B2-025

quantity :

25 ug

price :

432 USD

more info or order :

R&D Systems product webpage

citations: 9

Reference
Shahin W, Ebed S, Tyler S, Miljkovic B, Choi S, Zhang Y, et al. Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate. Nat Commun. 2023;14:444 pubmed publisher
Caldwell A, Sancho L, Deng J, Bosworth A, Miglietta A, Diedrich J, et al. Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders. Nat Neurosci. 2022;25:1163-1178 pubmed publisher
Akashi Y, Nagasaki A, Okawa H, Matsumoto T, Kondo T, Yatani H, et al. Cyclic Pressure-Induced Cytokines from Gingival Fibroblasts Stimulate Osteoclast Activity: Clinical Implications for Alveolar Bone Loss in Denture Wearers. J Prosthodont Res. 2022;: pubmed publisher
Gu W, Nowak W, Xie Y, Le Bras A, Hu Y, Deng J, et al. Single-Cell RNA-Sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2019;39:2049-2066 pubmed publisher
Ichijo R, Kobayashi H, Yoneda S, Iizuka Y, Kubo H, Matsumura S, et al. Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration. Nat Commun. 2017;8:508 pubmed publisher
Hellbach N, Weise S, Vezzali R, Wahane S, Heidrich S, Roidl D, et al. Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014;23:6177-90 pubmed publisher
Yamada P, Mehta H, Hwang D, Roos K, Hevener A, Lee K. Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation. Endocrinology. 2010;151:5741-50 pubmed publisher
Villani R, Adolphe C, Palmer J, Waters M, Wainwright B. Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prev Res (Phila). 2010;3:1222-34 pubmed publisher
Raina K, Blouin M, Singh R, Majeed N, Deep G, Varghese L, et al. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2007;67:11083-91 pubmed

product information

brand :

R&D Systems

master code :

797-B2

SKU :

797-B2-025

product name :

Recombinant Mouse IGFBP-2 Protein, CF

unit size :

25 ug

seo description :

The Recombinant Mouse IGFBP-2 Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse IGFBP-2 Protein, CF has been validated for the following applications: Bioactivity.

target :

IGFBP-2

category :

Proteins and Enzymes

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Acetonitrile and TFA.

conjugate :

Unconjugated

dilution :

Bioactivity

purity :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

species :

Mouse

observed molecular weight :

35 kDa, reducing conditions

theoretical molecular weight :

29.4 kDa

gene symbol :

Igfbp2

details of functionality :

Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7 human breast cancer cells. Karey, K.P. et al . (1988) Cancer Research 48 :4083. The ED50 for this effect is 0.125-0.5á╡g/mL in the presence of 30áng/mL rmIGF-II.

endotoxin note :

<0.01 EU per 1 ╡g of the protein by the LAL method.

accessionNumbers :

P47877

applications :

Bioactivity

source :

NS0-derived Recombinant Mouse IGFBP-2 Protein, CF

USD :

432 USD

alt names :

BP2, IBP2, IBP-2, IGF-binding protein 2, IGFBP2, IGFBP-2, IGF-BP53, insulin-like growth factor binding protein 2 (36kD), insulin-like growth factor binding protein 2, 36kDa, insulin-like growth factor-binding protein 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage