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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF
catalog :
796-IC-050
quantity :
50 ug
price :
300 USD
more info or order :
citations: 84
Reference
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Meehan G, Scales H, Osii R, De Niz M, Lawton J, Marti M, et al. Developing a xenograft model of human vasculature in the mouse ear pinna. Sci Rep. 2020;10:2058 pubmed publisher
Salz A, Gurniak C, Jönsson F, Witke W. Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus. J Cell Sci. 2020;133: pubmed publisher
Ren C, Yuan Q, Jian X, Randazzo P, Tang W, Wu D. Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization. J Immunol. 2020;204:1012-1021 pubmed publisher
Gülcüler Balta G, Monzel C, Kleber S, Beaudouin J, Balta E, Kaindl T, et al. 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Cell Rep. 2019;29:2295-2306.e6 pubmed publisher
Engelbertsen D, Autio A, Verwilligen R, Depuydt M, Newton G, Rattik S, et al. Increased lymphocyte activation and atherosclerosis in CD47-deficient mice. Sci Rep. 2019;9:10608 pubmed publisher
Schmid M, Khan S, Kaneda M, Pathria P, Shepard R, Louis T, et al. Integrin CD11b activation drives anti-tumor innate immunity. Nat Commun. 2018;9:5379 pubmed publisher
Chen J, Li N, Yin Y, Zheng N, Min M, Lin B, et al. Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells. Cell Rep. 2018;25:3393-3404.e6 pubmed publisher
Kimmerling R, Prakadan S, Gupta A, Calistri N, Stevens M, Olcum S, et al. Linking single-cell measurements of mass, growth rate, and gene expression. Genome Biol. 2018;19:207 pubmed publisher
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Farinazzo A, Angiari S, Turano E, Bistaffa E, Dusi S, Ruggieri S, et al. Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis. Sci Rep. 2018;8:7473 pubmed publisher
Praetner M, Zuchtriegel G, Holzer M, Uhl B, Schaubächer J, Mittmann L, et al. Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion. Arterioscler Thromb Vasc Biol. 2018;38:829-842 pubmed publisher
Paetau S, Rolova T, Ning L, Gahmberg C. Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia. Front Mol Neurosci. 2017;10:431 pubmed publisher
Adutler Lieber S, Zaretsky I, Sabany H, Kartvelishvily E, Golani O, Geiger B, et al. Substrate-bound CCL21 and ICAM1 combined with soluble IL-6 collectively augment the expansion of antigen-specific murine CD4+ T cells. Blood Adv. 2017;1:1016-1030 pubmed publisher
Ju L, Chen Y, Li K, Yuan Z, Liu B, Jackson S, et al. Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species. Sci Rep. 2017;7:14185 pubmed publisher
Basole C, Nguyen R, Lamothe K, Vang A, Clark R, Baillie G, et al. PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cell Signal. 2017;40:62-72 pubmed publisher
Borger J, Morrison V, Filby A, Garcia C, Uotila L, Simbari F, et al. Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells. J Immunol. 2017;199:874-884 pubmed publisher
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Hirano Y, Yang W, Aziz M, Zhang F, Sherry B, Wang P. MFG-E8-derived peptide attenuates adhesion and migration of immune cells to endothelial cells. J Leukoc Biol. 2017;101:1201-1209 pubmed publisher
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Kim G, Lee Y, Kwon J, Jun H, CHOU J. Glycogen storage disease type Ib neutrophils exhibit impaired cell adhesion and migration. Biochem Biophys Res Commun. 2017;482:569-574 pubmed publisher
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Parzmair G, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, et al. ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens. J Leukoc Biol. 2017;101:407-419 pubmed publisher
Csépányi Kömi R, Wisniewski E, Bartos B, Lévai P, Nemeth T, Balazs B, et al. Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice. J Immunol. 2016;197:2807-15 pubmed publisher
Xu X, Wang X, Todd E, Jaeger E, Vella J, Mooren O, et al. Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration. J Immunol. 2016;197:1683-91 pubmed publisher
Cheung S, Ostergaard H. Pyk2 Controls Integrin-Dependent CTL Migration through Regulation of De-Adhesion. J Immunol. 2016;197:1945-56 pubmed publisher
Köchl R, Thelen F, Vanes L, Brazão T, Fountain K, Xie J, et al. WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol. 2016;17:1075-83 pubmed publisher
Rudolph H, Klopstein A, Gruber I, Blatti C, Lyck R, Engelhardt B. Postarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro. Eur J Immunol. 2016;46:2187-203 pubmed publisher
Palmer E, Drobek A, Stepanek O. Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice. Eur J Immunol. 2016;46:1887-901 pubmed publisher
Zuchtriegel G, Uhl B, Puhr Westerheide D, Pörnbacher M, Lauber K, Krombach F, et al. Platelets Guide Leukocytes to Their Sites of Extravasation. PLoS Biol. 2016;14:e1002459 pubmed publisher
Martin Blondel G, Pignolet B, Tietz S, Yshii L, Gebauer C, Périnat T, et al. Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin. Eur J Immunol. 2015;45:3302-12 pubmed publisher
Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson L, McEver R. Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow. J Immunol. 2015;195:3880-9 pubmed publisher
Yago T, Petrich B, Zhang N, Liu Z, Shao B, Ginsberg M, et al. Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. J Exp Med. 2015;212:1267-81 pubmed publisher
Na B, Kim H, Piragyte I, Oh H, Kwon M, Akber U, et al. TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol. 2015;209:143-62 pubmed publisher
Huang Y, Clarke F, Karimi M, Roy N, Williamson E, Okumura M, et al. CRK proteins selectively regulate T cell migration into inflamed tissues. J Clin Invest. 2015;125:1019-32 pubmed publisher
Germena G, Volmering S, Sohlbach C, Zarbock A. Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation. J Immunol. 2015;194:728-38 pubmed publisher
Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, et al. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med. 2014;211:1993-2011 pubmed publisher
Camirand G, Wang Y, Lu Y, Wan Y, Lin Y, Deng S, et al. CD45 ligation expands Tregs by promoting interactions with DCs. J Clin Invest. 2014;124:4603-13 pubmed publisher
Morrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, et al. Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014;211:1957-68 pubmed publisher
Xu X, Jaeger E, Wang X, Lagler Ferrez E, Batalov S, Mathis N, et al. Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration. PLoS ONE. 2014;9:e105561 pubmed publisher
Palmi C, Fazio G, Savino A, Procter J, Howell L, Cazzaniga V, et al. Cytoskeletal regulatory gene expression and migratory properties of B-cell progenitors are affected by the ETV6-RUNX1 rearrangement. Mol Cancer Res. 2014;12:1796-806 pubmed publisher
Knowlden S, Capece T, Popovic M, Chapman T, Rezaee F, Kim M, et al. Regulation of T cell motility in vitro and in vivo by LPA and LPA2. PLoS ONE. 2014;9:e101655 pubmed publisher
Göbel K, Schuhmann M, Pankratz S, Stegner D, Herrmann A, Braun A, et al. Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. Eur J Immunol. 2014;44:2295-305 pubmed publisher
Wang X, Rodda L, Bannard O, Cyster J. Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness. J Immunol. 2014;192:4601-9 pubmed publisher
Jung H, Song K, Chang J, Doh J. Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays. PLoS ONE. 2014;9:e91926 pubmed publisher
Jenkins M, Stinchcombe J, Au Yeung B, Asano Y, Ritter A, Weiss A, et al. Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. elife. 2014;3:e01310 pubmed publisher
Korthals M, Schilling K, Reichardt P, Mamula D, Schlüter T, Steiner M, et al. ?PIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes. J Immunol. 2014;192:3228-38 pubmed publisher
Foley M, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, et al. High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. PLoS ONE. 2014;9:e87873 pubmed publisher
Bosticardo M, Musio S, Fontana E, Angiari S, Draghici E, Constantin G, et al. Development of central nervous system autoimmunity is impaired in the absence of Wiskott-Aldrich syndrome protein. PLoS ONE. 2014;9:e86942 pubmed publisher
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Dalli J, Norling L, Montero Melendez T, Federici Canova D, Lashin H, Pavlov A, et al. Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis. EMBO Mol Med. 2014;6:27-42 pubmed publisher
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product information
brand :
R&D Systems
master code :
796-IC
SKU :
796-IC-050
product name :
Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF
unit size :
50 ug
seo description :
The Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
target :
ICAM-1/CD54
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS.
conjugate :
Unconjugated
dilution :
Bioactivity
purity :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie« Blue Staining.
species :
Mouse
observed molecular weight :
110-130 kDa, reducing conditions
theoretical molecular weight :
76.8 kDa (monomer)
gene symbol :
Icam1
details of functionality :
Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells. When 5 x 104 cells/well are added to rmICAM/Fc Chimera coated plates (12.5 ╡g/mL with 100 ╡L/well), approximately 65-95% will adhere after 1 hour incubation at 37 ░C. Optimal dilutions should be determined by each laboratory for each application.
endotoxin note :
<0.10 EU per 1 ╡g of the protein by the LAL method.
accessionNumbers :
Q3U8M7
applications :
Bioactivity
source :
NS0-derived Recombinant Mouse ICAM-1/CD54 Fc Chimera Protein, CF
USD :
300 USD
alt names :
BB2, CD54, CD54 antigen, cell surface glycoprotein P3.58, human rhinovirus receptor, ICAM1, ICAM-1, intercellular adhesion molecule 1, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor, Major group rhinovirus receptor, P3.58
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 3 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.