product summary
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company name :
R&D Systems
product type :
protein
product name :
Recombinant Mouse IL-17A (CHO-expressed) Protein
catalog :
7956-ML-025
quantity :
25 ug
price :
300 USD
more info or order :
R&D Systems product webpage
citations: 5
Reference
Lv X, Lv S, Wang G, Chang Y, Cai Y, Liu H, et al. Glia-derived adenosine in the ventral hippocampus drives pain-related anxiodepression in a mouse model resembling trigeminal neuralgia. Brain Behav Immun. 2024;117:224-241 pubmed publisher
Wayne C, Bremner L, Faust T, Dur xe1 n Laforet V, Ampatey N, Ho S, et al. Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis. bioRxiv. 2023;: pubmed publisher
Knizkova D, Pribikova M, Draberova H, Semberova T, Trivic T, Synackova A, et al. CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology. Nat Immunol. 2022;23:1644-1652 pubmed publisher
Byrne E, Llorián Salvador M, Tang M, Margariti A, Chen M, Xu H. IL-17A Damages the Blood-Retinal Barrier through Activating the Janus Kinase 1 Pathway. Biomedicines. 2021;9: pubmed publisher
Wang Y, Gao S, Gao S, Li N, Xie B, Shen X. Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy. Cell Biosci. 2021;11:82 pubmed publisher
product information
brand :
R&D Systems
catalog number base :
7956-ML
SKU :
7956-ML-025
product name :
Recombinant Mouse IL-17A (CHO-expressed) Protein
units size :
25 ug
description :
The Recombinant Mouse IL-17A (CHO-expressed) Protein from R&D Systems is derived from CHO. The Recombinant Mouse IL-17A (CHO-expressed) Protein has been validated for the following applications: Bioactivity.
target :
IL-17/IL-17A
category :
Proteins and Enzymes
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
species :
Mouse
observed molecular weight :
15 -22 kDa, reducing conditions
theoretical molecular weight :
15 kDa (monomer)
gene symbol :
Il17a
details of functionality :
Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.25-1.25 ng/mL.
endotoxin note :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q62386
applications :
Bioactivity
source :
CHO-derived Recombinant Mouse IL-17A (CHO-expressed) Protein
USD :
300 USD
alt names :
CTLA8, CTLA-8, CTLA8cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL17A, IL-17A, IL-17Acytotoxic T-lymphocyte-associated protein 8, IL-17CTLA-8, IL17interleukin-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin 17A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.